frameshift mutation

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Related to Frame shift mutation: point mutation, missense mutation

read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
HNH nuclease is reported to be involved in cleavage of complementary strand while Ruvc cleaves the non-complementary strand resulting in the blunt end formation which after re-union gives frame shift mutations or indels [9]
The mutations are divided into two main categories:[sup][50] (1) N-terminal frame shift mutations that result in the occurrence of a termination codon, leading to an increased production of a nonfunctional truncated protein of 30 kDa; (2) C-terminal in-frame mutations in the bZIP domain, leading to proteins with disrupted homo- and hetero-dimerization domains and impaired DNA binding activities.
Until quite recently, point mutations or frame shift mutations had been identified only in a restricted number of genes including Runx1/AML1, (33) C/ EBP[alpha] (34) and Ras (35) in MDS patients.