frameshift mutation(redirected from Frame shift mutation)
Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.
The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation