CX3CR1

(redirected from Fractalkine receptor)

CX3CR1

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for fractalkine, a transmembrane protein and chemokine involved in leukocyte adhesion and migration. CX3CR1 is also a coreceptor for HIV-1; some alternatively spliced forms of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
References in periodicals archive ?
Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice.
Also, cancer cells that have the Fractalkine receptor on their surface migrate towards nerve ends that have Fractalkine on their surface.
Two regions, each of which contained a single nucleotide polymorphism (SNP) site of the fractalkine receptor gene, were amplified.
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease phenotype.
Fractalkine receptor polymorphism and chronic tonsillitis.
Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.
In contrast, fractalkine had no effect in mice or islets when the fractalkine receptor was deleted.