hantavirus pulmonary syndrome

(redirected from Four Corners Disease)

hantavirus pulmonary syndrome

a febrile disease caused by several species of Hantavirus (Andes, Bayou, Black Creek Canal, New York, and Sin Nombre viruses) in North and South America and characterized by thrombocytopenia, leukocytosis, and capillary leakage in the lungs, with death due to shock and cardiac complications.
An often fatal respiratory tract infection with massive acute pulmonary edema often at death caused by a hantavirus; the first cluster occurred in the Four Corners region of Southwestern US
Epidemiology Mean age 32, 61% women, 72% Native American
Case definition Unexplained bilateral interstitial infiltrates on chest films, arterial O2 saturation < 90%
Prodrome Fever, myalgia (100%), cough or shortness of breath (75%), GI symptoms, headache, tachycardia, tachypnea, hypotension
Lab Leukocytosis—± 26 x 109/L—often with myeloid precursors, increased haematocrit, thrombocytopaenia of ±64 x 109/L, increased PT, increased aPTT, increased LD, decreased serum protein, proteinuria
Prevention Vaccine is being developed

hantavirus pulmonary syndrome

An often fatal RTI caused by a hantavirus; the first cluster occurred in the Four Corners region of Southwestern US Epidemiology Mean age 32, 61% ♀, 72% Native American Case definition Unexplained bilateral interstitial infiltrates on chest film, arterial O2 saturation < 90% Prodrome Fever, myalgia-100%, cough or SOB-76%, GI Sx, headache, tachycardia, tachypnea, hypotension Lab Leukocytosis–± 26 x 109/L, often with myeloid precursors, ↑ Hct, thrombocytopenia of ±64 x 109/L, ↑ PT, ↑ aPTT, ↑ LD, ↓ serum protein, proteinuria Diagnosis Immunohistochemistry, Western blot, ELISA, IgM capture ELISA; massive acute pulmonary edema is common at death

Han·ta·vi·rus pul·mo·na·ry syn·drome

(hahn'tă-vī'rŭs pul'mŏ-nar-ē sin'drōm)
A febrile disease caused by several species of Hantavirus (Andes, Bayou, Black Creek Canal, New York, and Sin Nombre viruses) in North and South America and characterized by thrombocytopenia, leukocytosis, and capillary leakage in the lungs, with death due to shock and cardiac complications.

hantavirus pulmonary syndrome

Acute respiratory illness featuring a brief period of fever, muscle pains, headache, nausea and cough followed by severe shock and pulmonary oedema simulating the acute adult RESPIRATORY DISTRESS SYNDROME (ARDS). The mortality without specific treatment is 50–75 per cent but the drug ribavirin is effective. The disease is caused by a strain of hanta virus and was originally though to be acquired only from rodents. Human case-to-case infection has now been demonstrated.
References in periodicals archive ?
In nearby Gallup and Albuquerque, newspapers and broadcast stations referred to the deadly virus as "the mystery illness" or "the Four Corners disease" (the Navajo Nation covers 25,000 square miles of Arizona, New Mexico and Utah and borders Colorado).