founder effect

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Related to Founder population: Founder principle, Founder event

found·er ef·fect

an unusually high frequency of a gene in a particular population derived from a small set of unrepresentative ancestors.
Farlex Partner Medical Dictionary © Farlex 2012

founder effect

n.
A random difference in allele frequencies of a population founded by a small group of organisms relative to the allele frequencies in the original population.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

founder effect

the result of starting a new population with a low number of individuals (founders), so that their GENE POOL may not contain the same proportions of ALLELES for a particular LOCUS as in the original population. For example, instead of containing three alleles of the ABO BLOOD GROUP locus, Australian aborigines contain no B alleles and thus no Group B or Group AB individuals are produced, a situation probably caused by a ‘founder effect’. Such small founder populations are subject to RANDOM GENETIC DRIFT.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Further studies are necessary in larger samples to examine the role of these prediction models comprehensively in the Afrikaner founder population. However, in this study, the BOADICEA prediction model provided a good additional indication as to whether or not further testing was warranted.
To help conserve the breed, founder populations were collected.
Molecular-marker based estimates of relatedness could be used to assemble a founder population within these limitations that minimizes relatedness among individuals, maximizes genetic diversity, and minimizes inbreeding even if the natural population has substantial levels of family structure.
Ultimately, gerontologists hope founder population studies yield results that will help prevent certain age-related diseases.
The Newfoundland and Labrador Centre for Health Information database contains health records for more than 3,200 patients with psoriasis from this genetically distinct founder population.
Do you mean a founder population of as few as three individuals?
Some scientists reasoned that although not all of the components required for a successful WGAS were available at that time, use of a founder population, similar to that used to enhance disease-gene detection using family-linkage studies, would compensate for the deficiencies.
The introduced founder population fragmented, and by fall 1980, wood bison were found near Fort Nelson, British Columbia, 250 km south of the initial release site.
The company has exclusive access to the world's most comprehensive DNA and data bank, derived from the Eastern Finnish founder population. Together with a proprietary sequencing method, HPTS, this population allows the company to carry out gene discovery research on a significantly lower number of samples than is possible using other populations.
This research represents the first attempt by a private landowner, state, or federal agency to reintroduce a population of RCWs where no founder population exists.
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma.
Because individuals can be expected to select sites of the highest suitability, a founder population may initially grow at a high rate.