lanthanum carbonate


Pharmacologic class: Phosphate binder

Therapeutic class: Renal and genitourinary agent

Pregnancy risk category C


Dissociates in acidic environment of upper GI tract to release lanthanum ions, which bind dietary phosphate released from food during digestion and inhibit phosphate absorption by forming highly insoluble lanthanum phosphate complexes


Tablets (chewable): 500 mg, 750 mg, 1,000 mg

Indications and dosages

To reduce serum phosphate level in patients with end-stage renal disease

Adults: Initially, 1,500 mg P.O. (chewed) daily in divided doses with meals; titrate every 2 to 3 weeks until serum phosphate falls to acceptable level.


• Bowel obstruction, ileus, or fecal impaction


Use cautiously in:

• acute peptic ulcer, Crohn's disease, ulcerative colitis

• pregnant or breastfeeding patients

• children (safety and efficacy not established).


• Give before meals; ensure that patient chews tablets completely before swallowing to reduce risk of serious adverse GI events.

Adverse reactions

CNS: headache

CV: hypotension

GI: nausea, vomiting, diarrhea, constipation, abdominal pain

Metabolic: hypercalcemia

Respiratory: bronchitis, rhinitis

Other: dialysis graft complication or occlusion


Drug-diagnostic tests. Serum calcium: increased

Patient monitoring

• Monitor serum calcium and phosphorus levels periodically.

Patient teaching

• Instruct patient to take drug with or immediately after meals and to chew tablets completely before swallowing.

• Advise patient to discuss any planned dietary changes with prescriber.

• Inform female patient with childbearing potential that drug isn't recommended during pregnancy.

• Instruct female patient to tell prescriber if she's breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

lanthanum carbonate

(lan-than-um) ,


(trade name)


Therapeutic: hypophosphatemics
Pharmacologic: phosphate binders
Pregnancy Category: C


Reduction of serum phosphate levels associated with end-stage renal disease.


Dissociates in the upper GI tract forming lanthanate ions, which form an insoluble complex with phosphate.

Therapeutic effects

Decreased serum phosphate levels.


Absorption: Negligible absorption.
Distribution: Stays within the GI tract.
Metabolism and Excretion: Eliminated almost entirely in feces.
Half-life: 53 hr (in plasma).

Time/action profile (effect on phosphate levels)

POunknown2–3 wkunknown


Contraindicated in: Bowel obstruction;Ileus;Fecal impaction; Obstetric: Congenital abnormalities noted in animal studies; Pediatric: Potential negative effect on developing bone.
Use Cautiously in: Patients with risk factors for bowel obstruction, including history of GI surgery, colon cancer, constipation, ileus, diabetes, or taking medications that cause constipation; Lactation: Safety not established.

Adverse Reactions/Side Effects


  • nausea (most frequent)
  • vomiting (most frequent)
  • diarrhea
  • fecal impaction
  • GI obstruction
  • ileus

Fluid and Electrolyte

  • hypocalcemia


Drug-Drug interaction

May ↓ abosrption of fluoroquinolones, tetracyclines, and levothyroxine ; administer at least 1 hr before or 3 hr after lanthanum carbonate.


Oral (Adults) 1500 mg/day in divided doses; may be titrated upward every 2–3 wk in increments of 750 mg/day up to 4500 mg/day (usual range 1500–3000 mg/day).


Chewable tablets: 500 mg, 750 mg, 1000 mg

Nursing implications

Nursing assessment

  • Assess patient for nausea and vomiting during therapy.
  • Lab Test Considerations: Monitor serum phosphate levels prior to and periodically during therapy.

Potential Nursing Diagnoses

Nausea (Side Effects)


  • Do not confuse lanthanum carbonate with lithium carbonate.
  • Divide total daily dose and administer with meals.
  • Oral: Administer with or immediately after meals. Tablets should be crushed or chewed completely before swallowing; intact tablets should not be swallowed.

Patient/Family Teaching

  • Instruct patient to take lanthanum as directed.

Evaluation/Desired Outcomes

  • Decrease in serum phosphate to below than 6.0 mg/dL in patients with end stage renal disease.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
Lanthanum carbonate, the generic equivalent of Shire Development LLC's Fosrenol, is indicated to reduce serum phosphate in patients with endstage renal disease (ESRD).
(Fosrenol) powder packet Accumulation in bone observed.
Noncalcium-phosphate binders (Fosrenol) and tumor resection were advised but the patient refused because of economic condition and he was discharged from hospital.
17 September 2010 - Swedish Orphan Biovitrum (STO: SOBI) saidA yesterday that it will discontinue its marketing, distribution and medical support of Xagrid, Fosrenol, and Equasym in the Nordic countries when the various distribution contracts with UK pharmaceutical company Shire PlcA (LON: SHP) expire during 2011.
The lawsuit was filed in response to an ANDA (Abbreviated New Drug Application) filed by Natco seeking FDA approval to market and sell generic versions of Shire's 500 mg, 750 mg, and 1 g FOSRENOL (Lanthanum Carbonate) products.
Weitzman, an endocrinologist at Stony Brook (N.Y.) University, examined the interaction of levothyroxine with two relatively new drugs--colesevelam (Welchol), the newest bile acid sequestrant approved for hyperlipidemia and diabetes; and lanthanum carbonate (Fosrenol), a new phosphate binder used in end-stage renal disease.
Weitzman, an endocrinologist at Stony Brook University, New York, examined the interaction of levothyroxine with two relatively new drugs--colesevelam (Welchol), the newest bile acid sequestrant approved for hyperlipidemia and diabetes; and lanthanum carbonate (Fosrenol), a new phosphate binder used in end-stage renal disease.
Prior to his tenure at Erimos, Dr Frazer served as the Vice President, Clinical Research at Shire Pharmaceuticals where he was responsible for clinical drug development of key programs that included Adderall XR, Equetro and Fosrenol. Dr Frazer obtained his BSc and medical degree from the University of Edinburgh Medical School.
The program covers commonly prescribed bone disease medications, including Fosrenol, Hectorol, Phoslo, Renagel, Sensipar, and Semplar.
Shire Pharmaceuticals was yesterday celebrating approval from US regulators for the launch of its Fosrenol treatment for patients with kidney disease.
Drugs group Shire Phar-maceuticals did well after winning the approval of US regulators for its Fosrenol treatment for patients with severe kidney disease.