formoterol fumarate

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Related to formoterol fumarate: budesonide, Salmeterol

formoterol fumarate

Atimos Modulite (UK), Foradil (UK), Foradil Aerolizer, Oxeze (CA), Oxis (UK), Perforomist

Pharmacologic class: Sympathomimetic; long-acting, selective beta2-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category C


Stimulates intracellular adenylate cyclase, relaxing bronchial smooth muscle and inhibiting release of mediators of immediate hypersensitivity


Capsules for oral inhalation (used with Aerolizer inhaler): 12 mcg

Indications and dosages

Long-term maintenance of asthma; prevention or long-term maintenance of bronchospasm in patients with chronic obstructive pulmonary disease

Adults and children ages 5 and older: Contents of 1 capsule inhaled orally via Aerolizer q 12 hours

Acute prevention of exercise-induced bronchospasm (on occasional, as-needed basis)

Adults and children ages 5 and older: Contents of 1 capsule inhaled orally via Aerolizer at least 15 minutes before start of exercise. Wait 12 hours after initial dose before giving repeat dose.


• Hypersensitivity to drug or its components

• Tachyarrhythmias


Use cautiously in:

• acute asthma symptoms, deteriorating asthma, cardiovascular disorders, seizure disorders, thyrotoxicosis, diabetes, possible hypokalemia

• patients older than age 75

• labor

• pregnant or breastfeeding patients

• children younger than age 5.


• Be aware that drug is not intended for acute asthma attacks.

• Use capsules only with Aerolizer inhaler supplied.

• Keep capsules in blister until immediately before use.

Make sure patient doesn't swallow capsules.

Adverse reactions

CNS: tremor, dizziness, insomnia, anxiety

CV: chest pain

EENT: sinusitis, pharyngitis, tonsillitis

GI: dry mouth

Metabolic: hypokalemia, hyperglycemia

Musculoskeletal: muscle cramps, back pain, leg cramps

Respiratory: bronchitis, chest infection, dyspnea, upper respiratory tract infection, increased sputum

Skin: pruritus, rash

Other: dysphonia, viral infection, fever


Drug-drug. Adrenergics: potentiation of formoterol's sympathomimetic effects

Beta-adrenergic blockers: partial or total inhibition of formoterol's effects

Cardiac glycosides, methylxanthines, potassium-wasting diuretics, steroids: potentiation of formoterol's hypokalemic effects, increased risk of arrhythmias

Disopyramide, MAO inhibitors, quinidine, phenothiazines, procainamide, tricyclic antidepressants: prolonged QTc interval, increased risk of ventricular arrhythmias

Halogenated hydrocarbon anesthetics: increased risk of arrhythmias

Levodopa, levothyroxine, oxytocin: impaired cardiac tolerance of formoterol

Drug-diagnostic tests. Blood glucose: increased level

Potassium: decreased level

Drug-behaviors. Alcohol use: impaired cardiac tolerance of formoterol

Patient monitoring

• Monitor pulmonary function test results.

• Monitor potassium and glucose levels.

Patient teaching

• Teach patient how to use capsules and Aerolizer inhaler provided.

• Instruct patient to keep capsules in blisters until immediately before use.

• Caution patient not to swallow capsules.

• Tell patient not to use drug for acute asthma attacks.

Instruct patient to contact prescriber immediately if difficulty in breathing persists after using drug or if condition worsens.

• Caution patient to take drug exactly as prescribed and not to stop therapy even if he feels better.

• Tell patient to consult prescriber if he has been taking inhaled, short-acting drugs on a regular basis.

• Advise female patient to tell prescriber if she is pregnant or breastfeeding or if she plans to become pregnant.

• Caution patient to avoid alcohol during therapy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

formoterol fumarate

(fôr-mō′tə-rôl′, -rōl′)
A drug used in the treatment of asthma, the prevention of bronchospasm, and the maintenance treatment of chronic obstructive pulmonary disease.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
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References in periodicals archive ?
Stock standard solutions of aclidinium bromide and formoterol fumarate dihydrate (100 [micro]g/mL) were prepared by dissolving 10 mg of each drug in 75 mL methanol, and the volume was completed to 100 mL with the same solvent.
The FDA also has granted the long-acting beta-2 agonist formoterol fumarate tentative approval for use as monotherapy.
TORONTO--No long-term safety signals were seen in a randomized trial that tested the formoterol fumarate inhalation solution against placebo in patients with moderate to severe chronic obstructive pulmonary disease.
Those who were on monotherapy with tiotropium (Spiriva) had significantly lower rates of disease-related hospital admissions during 12 months of follow-up than those using salmeterol (Serevent), formoterol fumarate (Foradil), salmeterol / fluticasone propionate (Advair), or combination therapy with two or more LABDs, said Dr.
Foradil Certihaler (formoterol fumarate inhalation powder, Novartis Pharmaceuticals)
Pearl's lead product, PT003, is a fixed-dose combination of formoterol fumarate, a long-acting beta-2 agonist (LABA) and glycopyrrolate, a long-acting muscarinic antagonist (LAMA).
ORLANDO - A combination of fixed-dose mometasone furoate and formoterol fumarate improved lung function in patients with moderate to very severe chronic obstructive pulmonary disease.
* Recommended Dosage: Symbicort is available in two strengths: 4.5 mcg of formoterol fumarate dihydrate combined with either 80 mcg or 160 mcg budesonide per inhalation.
has received Food and Drug Administration approval for Dulera (mometasone furoate and formoterol fumarate dihydrate) inhalation aerosol, a fixed-dose combination asthma treatment for patients age 12 and older.
Those on monotherapy with tiotropium (Spiriva) had significantly lower rates of disease-related hospital admissions during 12 months of follow-up than those on salmeterol (Serevent), formoterol fumarate (Foradil), salmeterol/fluticasone propionate (Advair), or combination therapy with two or more LABDs, said Dr.
Foradil Aerolizer (formoterol fumarate), made by Novartis AG, is included in the health advisory.