Of the proteins the researchers examined, the pattern of two proteins, Activin A and follistatin
, stood out from the rest.
In mice engineered to either overproduce follistatin
or not produce Activin A at all, hair cells were late to form and appeared disorganized and scattered across multiple rows inside the cochlea.
ACE-083, a locally-acting therapeutic candidate based on the naturally-occurring protein follistatin
, utilizes the Myostatin+ approach to inhibit multiple TGF-beta superfamily ligands.
FGF7, FGF10, PDGF, Irisin, SCF, TIMP2, Follistatin
, BMP2, Midkine, and Gremlinl can be made available upon request.
6u-39EW]; Janaiah Kota et al., Follistatin
Gene Delivery Enhances Muscle
Potential local regulatory functions of inhibins, activins and follistatin
in the ovary.
regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation.
Key growth factors within HSC660 include KGF, VEGF, and follistatin
, which have been shown to be important in hair formation and the stimulation of resting hair follicles.
Immediate onset of DNA synthesis in remnant rat liver after 90% hepatectomy by an administration of follistatin
. J Hepatol 1998;28:977-84.
Analysis of the effects of androgens and training on myostatin propeptide and follistatin
concentrations in blood and skeletal muscle using highly sensitive Immuno PCR.
, another myostatin inhibitor, increased fusion index and myogenic protein expression (including MyoD, Myf5, and myogenin) in C2C12 cells .
The principal markers of the inflammatory state include C-reactive protein (CRP), tumor necrosis factor alpha (TNF-[alpha]), homocysteine (Hcy), interleukins 1 and 6 (IL-1, IL-6), follistatin
, and total number of white blood cells (WBCs) [3-8].