estrone

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estrone

 [es´trōn]
an estrogen isolated from pregnancy urine, the human placenta, and palm kernel oil, and also prepared synthetically; used in estrogen replacement therapy for hypogonadism, ovariectomy, primary ovarian failure, atrophic vaginitis, vasomotor menopausal symptoms such as hot flashes, and vulvar atrophy, and in the treatment of dysfunctional uterine bleeding and advanced prostate cancer. Administered intramuscularly or intravaginally. See also conjugated estrogens and esterified estrogens.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

es·trone (E1),

(es'trōn),
A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta; has considerably less biologic activity than the parent hormone.
Farlex Partner Medical Dictionary © Farlex 2012

estrone

(ĕs′trōn′)
n.
An estrogenic hormone, C18H22O2, that is secreted by the ovaries and by fatty tissue. It is the main form of estrogen in postmenopausal women.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

estrone

E1 An estrogen with very low biologic activity that is the major source of estrogen in children and postmenopausal ♀ ↑ in pregnancy, postmenopausal, ↑ age, obesity, luteal phase of menstrual cycle ↓ in hypogonadism. See Androstendione.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

es·trone

(es'trōn)
A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta, with considerably less biologic activity than the parent hormone.
Synonym(s): oestrone.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Familial spontaneous pneumothorax and lung cysts due to a Folliculin exon 10 mutation.
Sharma et al., "Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling," Proceedings of the National Academy of Sciences of the United States of America, vol.
(85) The protein product of FLCN, known as folliculin, has been shown in cell culture and coimmunoprecipitation studies to interact with the mTOR pathway.
Folliculin encoded by the BHD gene interacts with abinding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.
(63) Shortly thereafter, the gene containing pathogenic mutations in BHD patients was identified and called folliculin. (64) The function of folliculin is still largely unknown, but it is thought to serve as a tumor-suppressor gene.

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