fetal hemoglobin

(redirected from Foetal haemoglobin)
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Related to Foetal haemoglobin: Hb F, Haemoglobin F

he·mo·glo·bin F

[MIM*142200]
normal fetal Hb (Hb F) of molecular formula α2Aγ2F, which is the major Hb component during intrauterine life, decreasing rapidly during infancy to reach a concentration of less than 0.5% in normal children and adults; the concentration of Hb F is increased in some hemoglobinopathies and in some cases of hypoplastic anemia, pernicious anemia, and leukemia; Hb F has a weaker affinity for 2,3-bisphosphoglycerate than does Hb A. More than 50 mutant variants of the γ chain have been reported.
Synonym(s): fetal hemoglobin

fetal hemoglobin

n.
The predominant form of hemoglobin in fetuses and newborn infants, present in small amounts in adults but often elevated in adults with certain forms of anemia and other disorders.

fetal hemoglobin

Hemoglobin F An immature Hb composed of 2 α and 2 γ chains that usually disappears in the neonatal period. See Hereditary persistence of fetal hemoglobin.
References in periodicals archive ?
Reliable routine estimation of small amounts of foetal haemoglobin by alkali denaturation.
The therapeutic efficacy of Hydroxyurea (HU) is attributed to induction of foetal haemoglobin and potentially to reduction of white blood cells as well as platelet counts, improved rheology and decreased endothelial red blood cell adhesion.
Although the exact mechanism of action remains uncertain, the therapeutic efficacy of HU is attributed to induction of foetal haemoglobin and potentially to reduction of white blood cell and platelet counts, improved rheology and decreased endothelial red blood cell adhesion.
She had been diagnosed at the age of two years, as suffering from homozygous thalassaemia on Hb electrophoresis, which had shown 97% foetal haemoglobin (HbF).
foetal haemoglobin is one of the biological factors thought to decrease morbidity in these patients.
Retinal vascular development is ideally accomplished, while the foetus is in the uterus in a relatively hypoxic environment [1] where average Pa[0.sub.2] is 25-35 kPa, which is supported by infant foetal haemoglobin and lower metabolic demands.