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The goal of fluid replacement is to correct electrolyte, fluid, and acid-base imbalances. The oral route of replacement is used if possible. The intravenous, intraperitoneal, or subcutaneous routes are also used, with the intravenous route being used most frequently. Fluids may be isotonic, hypotonic, or hypertonic; may contain certain crystalloids (e.g., sodium, potassium, chloride, or calcium); or may contain osmotically active substances (e.g., glucose, protein, starch, or a synthetic plasma volume expander such as dextran or hetastarch). The composition, rate of administration, and route depend on the clinical condition being treated.