5 bp long sequences are important for the binding of many enzymes including the methyltransferase; both methylases (LlaDII and Bsp6I R/M) have two recognition sites (5'-GCGGC-3' and 5'-GCCGC-3') [3-0] and 5'-CCCGC-3' is the recognition site of the DNA methyltransferase (methylase) FauIA (of the restriction-modification system FauI from Flavobacterium aquatile) 30].