Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism
during drug discovery and preclinical development.
Similar to pMDIs, a nasal spray offers similar dose size limitations, rapid onset, and bypasses the first-pass metabolism
Site and quantitative importance of alcohol first-pass metabolism
The main impact of liver disease is on phase I enzymes, which will affect both clearance and first-pass metabolism
Therefore the Sprague-Dawley rat liver microsomes may be useful for assessing herb-drug interaction in the hepatic first-pass metabolism
responsible for CYP1A2 at the early drug-discovery stage because of similar typical substrates and metabolism activities as humans.
5 h] after high-dose Sativex were facilitated THC absorption through the oral mucosa and reduced first-pass metabolism
Avoiding first-pass metabolism
in the liver prevents production of metabolites that can alter a drug's safety and side effect profile, said Dr.
Unfortunately, a major drawback of Invirase was its limited bioavailability due to incomplete absorption and extensive first-pass metabolism
It has recently been reported that alcohol dehydrogenase (ADH) activity in gastric mucosa contributes substantially to the first-pass metabolism
of ethanol, and that activities in the stomach are lower in women than in men.
Lieber notes that studies of males reported by his team in the February 1989 GASTROENTEROLOGY indicate that some drugs -- including cimetidine, widely presribed to control gastric ulcers -- can inhibit the stomach's first-pass metabolism
This approach considers separately the various mechanisms involved in drug absorption, such as transit time, gut wall permeability, gut wall metabolism, and hepatic first-pass metabolism
from dissolution rate.