This Phase 2 trial which is being conducted at SYSUCC in Guangzhou, China, and in collaboration with Guangxi Wuzhou Pharmaceutical Company, is designed to enroll up to 30 patients to determine whether first-line therapy
with VAL-083 treatment improves progression free survival.
As a result, countries like Kenya halted plans to make DTG-based regimens the preferred first-line therapy
Brenda Huppke, M.D., from the University Medical Center Göttingen in Germany, and colleagues examined the correlation of obesity with pediatric MS risk and first-line therapy
response in a retrospective study.
"With these new triplet regimens we hope to improve outcomes for both newly diagnosed patients as well as those who have relapsed or become refractory to first-line therapy
. IMiD agents have brought significant benefit to multiple myeloma patients and we are committed to advancing our pipeline of novel myeloma treatments in order to ensure physicians and patients continue to have new treatment options available to fight this disease."
MGTA-145 is a biologic chemokine factor that Magenta is developing as a first-line therapy
for stem cell mobilization.
The choice of treatment in a first-line therapy
setting is important as patients progressively become less responsive to therapy and experience shorter periods of remission at later lines of treatment.
"The new treatment could also become useful as a part of the first-line therapy
in the management of acute eye injuries experienced in the work place or at home arising from exposure to caustic chemicals, scalding liquids or excessive heat." The new treatment could be available to patients within as little as a few years, subject to completion of rigorous clinical trials, Harkin noted.
A topical retinoid plus topical benzoyl peroxide beats antibiotics as the first-line therapy
for most patients with inflammatory acne, according to the consensus of an international panel of dermatologists, led by Diane M.
The planned Phase Ib/II, open-label, multicenter, randomized trial will enroll patients with metastatic HR+, HER2-breast cancer who have experienced disease progression during or following first-line therapy
. Genentech will be responsible for conducting the trial.
"The reason that pediatricians and others like to reserve the use of amoxicillin as first-line therapy
for children with AOM is that it is generally effective, it's safe, it's narrow in spectrum, and it's relatively inexpensive.
After reviewing studies of how well these drugs perform, a committee of the American College of Physicians has recommended metformin as first-line therapy
for type 2 diabetes.