gene mapping

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Related to Fine-mapping: gene mapping, genetic map

ge·net·ic map

an abstract representation of the ordered array of genetic loci such that the interval between entries has algebraic signs and magnitude proportional to the expected number of crossings over between them and distances are algebraically additive; for example, on a genetic map the combined distance between locus A and locus C is the algebraic sum of the two distances between loci A and B, and B and C.

gene mapping

Determining the location of hereditary information carried on chromosomes. In humans, this requires determining the base pairs (chemical code) of each of the estimated 20,000 to 25,000 genes. Once a gene is mapped, that information may be used to compare abnormal genes with normal ones. Molecular biological techniques may then be used to search for methods of treating and preventing conditions resulting from genetic abnormality.
Synonym: genome mapping; linkage map See: gene splicing
See also: mapping
References in periodicals archive ?
The ImmunoChip is a dense fine-mapping genotype array that contains ~196,000 SNPs from 184 genes associated with at least one of 12 autoimmune diseases, including SLE.
In this fine-mapping study we examined two understudied Malaysian populations to replicate previously known SLE genetic associations and to localize the most associated SNP within known SLE genes.
(2002) proposed a fine-mapping method that was based on the evolutionary history of adjacent markers under a coalescent model.
(2002) with the addition of a hierarchical haplotype clustering step in the QTL fine-mapping analysis, which clustered haplotype groups that were based on kinship relatedness and effectively solved numerical computation problems, e.g.
Attempts have been made to reduce the size of the regions identified as containing major QTLs through "fine-mapping" in studies such as the one reported by Paterson et al.
This region has been targeted for fine-mapping and it was found that there were at least two smaller QTLs (Graham et al., 1997).
Fine-mapping milk production quantitative trait loci on BTA6: analysis of the bovine osteopontin gene.
ABSTRACT : A fine-mapping method exploiting linkage disequilibrium was used to detect quantitative trait loci (QTL) on the X chromosome affecting milk production, body conformation and productivity traits.
Evaluation of a fine-mapping method exploiting linkage disequilibrium in livestock populations: simulation study.
Fine-mapping of the intestinal receptor locus for enterotoxigenic Escherichia coli F4ac on porcine chromosome 13.