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An actin-binding protein that tightly cross-links adjacent filaments to form parallel actin fibers in vertebrate cells. It assists in maintaining cell polarity and development.
[L. fimbriae, threads, fibers, + -in]
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maitophilia fimbriae 1 (SMF-1), which is composed of fimbrin subunits and shares significant similarity with the N-terminal amino acid sequences of several fimbrial adhesins of pathogenic Escherichia coli strains and the Cup A fimbriae in Pseudomonas aeruginosa.
Antibodies to T- and L-isoforms of the cytoskeletal protein, fimbrin, in patients with systemic lupus erythematosus.
Several host cytoskeletal proteins are involved in tail formation, including [Alpha]-actinin (48), filamin (59), fimbrin (59), vasodilator-stimulated phosphoprotein (VASP) (60), vinculin (49,61), and neural-Wiskott-Aldrich syndrome protein (N-WASP) (63).