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An actin-binding protein that tightly cross-links adjacent filaments to form parallel actin fibers in vertebrate cells. It assists in maintaining cell polarity and development.
[L. fimbriae, threads, fibers, + -in]
Farlex Partner Medical Dictionary © Farlex 2012
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Matsudaira, "Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins," The Journal of Cell Biology, vol.
Ramagopal et al., "Structure of the actin crosslinking core of fimbrin," Structure, vol.
maitophilia fimbriae 1 (SMF-1), which is composed of fimbrin subunits and shares significant similarity with the N-terminal amino acid sequences of several fimbrial adhesins of pathogenic Escherichia coli strains and the Cup A fimbriae in Pseudomonas aeruginosa.
Kohsaka, "Microglia/ macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity," Journal of Neurochemistry, vol.
Originally pili were thought to be homopolymeric structures composed of approximately 1,000 copies of a single structural subunit (fimbrin) packed in a helical array.
Antibodies to T- and L-isoforms of the cytoskeletal protein, fimbrin, in patients with systemic lupus erythematosus.
Several host cytoskeletal proteins are involved in tail formation, including [Alpha]-actinin (48), filamin (59), fimbrin (59), vasodilator-stimulated phosphoprotein (VASP) (60), vinculin (49,61), and neural-Wiskott-Aldrich syndrome protein (N-WASP) (63).