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, filamin (fil'ă-min),
A high molecular weight, actin-binding protein that is part of the intracellular filamentous structure of fibroblastic cells; its distribution in cells is derived from its interaction with polymerized actin.
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References in periodicals archive ?
CM were collected from H2O2 treated MSCs (acutely senescent cells) following transfection with Filamin 3 siRNA or CD13 siRNA or control siRNA, respectively.
Clinical and morphological phenotype of the filamin myopathy: A study of 31 German patients.
Gene ID (NCBI) Full name (NCBI) FLNC 2318 Filamin C HIST2H2AA3/ 8337/ Histone cluster 2 H2A family member a3/ HIST2H2AC 8338 Histone cluster 2 H2A family member c HP 3240 Haptoglobin RRP8 23378 Ribosomal RNA processing 8, methyltransferase, homolog (yeast) U2SURP 23350 U2 snRNP associated SURP domain containing Gene Protein subgroup Reference FLNC Exclusive [87] HIST2H2AA3/ Exclusive [17] HIST2H2AC HP Overexpressed [42] RRP8 Exclusive [88] U2SURP Overexpressed [17] ID, identification number; NCBI, National Center for Biotechnology Information.
Bandaru et al., MMP-9 Filamin B (FLNB) suppresses the growth 2014 (26) and metastasis of human ovarian cancer by down-regulating the activity of MMP-9 and secretion of vascular endothelial growth factor-A (VEGF-A).
Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations.
Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.
Once filamin A leaves the cancerous cell's nucleus, that cell no longer requires androgens to survive.
Genes that have been implicated in Larsen syndrome include filamin B [2], whichisinvolvedinthe cytoskeletal architecture, and carbohydrate sulphotransferase 3, which has also been implicated in other skeletal dysplasias [3].
Kartogenin inhibits a protein called filamin A in the stem cells, an action that unleashes other compounds that switch on genes that ultimately trigger cartilage creation.
Naloxone binds to a scaffolding protein, filamin A, which interacts with the mu-opioid receptor to disrupt the morphine-induced mu-opioid receptor Gas coupling (68).
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.
Some of the genetic disorders associated with infantile spasms are X-linked cyclin-dependent kinase-like 5 (CDKL5 or Stk9) disruption, (6) deletion of the membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2) gene, (7) disruption of the serine/threonine kinase 9 gene, (8) distal 7q duplication syndrome, (9) expansion of the first PolyA tract of aristaless-related homeobox gene (ARX), (10) filamin A (FLNA) mutations, (11) and interstitial deletion of 7q.