Fibrosis


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Related to Fibrosis: Pulmonary fibrosis, Liver fibrosis

fibrosis

 [fi-bro´sis]
formation of fibrous tissue; see also fibroid degeneration. adj., adj fibrot´ic.
congenital hepatic fibrosis a developmental disorder of the liver, marked by formation of irregular broad bands of fibrous tissue containing multiple cysts formed by disordered terminal bile ducts, resulting in vascular constriction and portal hypertension.
cystic fibrosis (cystic fibrosis of pancreas) see cystic fibrosis.
diffuse idiopathic interstitial fibrosis (diffuse interstitial pulmonary fibrosis) idiopathic pulmonary fibrosis.
endomyocardial fibrosis an idiopathic type of myocardiopathy that is endemic in various parts of Africa and rarely in other areas, characterized by cardiomegaly, marked thickening of the endocardium with dense white fibrous tissue that may extend to involve the inner myocardium, and by congestive heart failure.
idiopathic pulmonary fibrosis chronic inflammatory progressive fibrosis of the pulmonary alveolar walls, with steadily progressive dyspnea, resulting in death from oxygen lack or right heart failure. Most cases are of unknown origin, although some are thought to result from pneumoconiosis, hypersensitivity pneumonitis, scleroderma, and other diseases.
mediastinal fibrosis development of hard white fibrous tissue in the upper portion of the mediastinum, sometimes obstructing the air passages and large blood vessels; called also fibrosing or fibrous mediastinitis.
periureteral fibrosis retroperitoneal fibrosis.
pleural fibrosis fibrosis of the visceral pleura so that part or all of a lung becomes covered with a plaque or a thick layer of nonexpansible fibrous tissue. The more extensive form is called fibrothorax.
postfibrinous fibrosis that occurring in tissues in which fibrin has been deposited.
proliferative fibrosis that in which the fibrous elements continue to proliferate after the original causative factor has ceased to operate.
pulmonary fibrosis idiopathic pulmonary fibrosis.
retroperitoneal fibrosis deposition of fibrous tissue in the retroperitoneal space, producing vague abdominal discomfort, and often causing blockage of the ureters, with resultant hydronephrosis and impaired renal function, which may result in renal failure. Called also Ormond disease.
fibrosis u´teri a morbid condition characterized by overgrowth of the smooth muscle and increase in the collagenous fibrous tissue of the uterus, producing a thickened, coarse, tough myometrium.

fi·bro·sis

(fī-brō'sis),
Formation of fibrous tissue as a reparative or reactive process, as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue.

fibrosis

(fī-brō′sĭs)
n.
The formation of excessive fibrous tissue, as in a reparative or reactive process.

fi·brot′ic (-brŏt′ĭk) adj.

fibrosis

Medtalk A proliferation of fibroblasts and fibrous tissue. See Bridging fibrosis, Hepatic fibrosis, Idiopathic interstitial fibrosis of lung, Pipestem fibrosis, Radiation fibrosis, Stellate fibrosis, Systemic idiopathic fibrosis.

fi·bro·sis

(fī-brō'sis)
Formation of fibrous tissue as a reparative or reactive process, as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue.

fibrosis

Scarring and thickening of any tissue or organ by the replacement of the original structure by simple collagenous FIBROUS TISSUE. This usually follows injury or inflammation. Fibrosis is the body's main healing process and the scar tissue formed is usually strong.

Fibrosis

Formation of fibrous tissue as a reaction or as a repair process; may occur due to treatment and/or disease. in lymphedema condition known as hardening of the limb with resulting restriction of circulatory flow, increased infection, and weeping sores.

fi·bro·sis

(fī-brō'sis)
Formation of fibrous tissue as a reparative or reactive process, as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue.

Patient discussion about Fibrosis

Q. Can cystic fibrosis patients have children? My boyfriend has cystic fibrosis, and currently he’s treated with many medications but usually healthy (other than pneumonia from hospitalization from time to time). I heard that men with cystic fibrosis can’t have children - is that true? Is there anything he can do about it?

A. WE ARE A HEALTHY COUPLE BUT MY WIFE NEVER GET PREGNANT IN 20 YEARS OF RELATIONSHIP.
I'M SO SORRY ABOUT MY ENGLISH, I'M LEARNING.

Q. Do women with cystic fibrosis have difficult pregnancy? My wife has cystic fibrosis, and after 3 year of marriage we decided we want a baby. I know that men with cystic fibrosis are usually infertile and can’t have children- is that the case also for women with cystic fibrosis? Is the pregnancy in women with cystic fibrosis more problematic? Is it dangerous?

A. Before you attempt a pregnancy, you should consult her doctor to make sure she can tolerate it, because very severe disease can make the pregnancy dangerous for her. If her disease isn’t so severe, usually there are no special problems.

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A. Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: http://www.pulmonaryfibrosis.org/ipf.htm Hope this helps.

More discussions about Fibrosis
References in periodicals archive ?
Various treatments exist to fight cystic fibrosis, including the correction of the cystic fibrosis gene.
The report on liver fibrosis drug market is a comprehensive study and presentation of drivers, restraints, opportunities, demand factors, market size, forecasts, and trends in the global liver fibrosis drug market over the period of 2017 to 2025.
"To my mind, the most important thing that our study could do is promote further research into this area to try and better characterize the role of aspirin for preventing fibrosis progression or preventing the development of NASH.
The atopy rates are higher in cystic fibrosis cases than in normal populations.
This randomised, double-blind 52-week study will assess improvement in fibrosis without worsening of NASH, adverse events and laboratory abnormalities in approximately 350 patients.
Purush Rao, MD, clinical associate professor of medicine at the Keck School of Medicine of USC, the adult cystic fibrosis clinic is focused on helping people with cystic fibrosis transition from paediatric to adult care.
Liver fibrosis and cirrhosis will continue to pose important diagnostic and therapeutic challenges to hepatologists.
"Obviously it's not an entire lung, but the technology can mimic the damaging effects of lung fibrosis. Ultimately, it could change how we test new drugs, making the process quicker and less expensive," said lead author Ruogang Zhao.
Liver biopsy always have some risk and complication as 84% have mild discomfort, 20% have pain, 0.3% have serious complication while 0.01% reported death.10 With the realization about limitation of liver bi-opsy hepatologists have increased their efforts to develop non-invasive tools for assessment of liver inflammation and fibrosis.11,12 Many research studies have proven that chronic HCV infection associated liver fibrosis is continuous dynamic as well as reversible process, needs frequent assessment for fibrosis stage before and during antifibrotic therapy.
The petition was started by Rhian Barrance, from Cardiff, whose best friend has a son with cystic fibrosis.
There are basically 2 views: one is that CHP is defined by time since the appearance of symptoms (variously described in the literature as greater than 3 months, 4 months, or 1 year) and/or the pattern of disease presentation ("recurrent," "insidious," versus "acute"); the other is that CHP is defined only by the presence of fibrosis either on imaging or from biopsy (reviewed in Salisbury et al (1) and Spagnolo et al (13)).