ITGA5(redirected from Fibronectin receptor subunit alpha)
ITGA5A gene on chromosome 12q11-q13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 5 undergoes post-translational cleavage in its extracellular domain, yielding disulfide-linked light and heavy chains that bind to a beta-1 chain, forming a fibronectin and fibrinogen receptor, which also participates in adhesion and cell surface-mediated signalling.
The alpha-5 beta-1 heterodimer interacts with extracellular HIV-1 Tat protein, and is thought to enhance angiogenesis in Kaposi's sarcoma.
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