fibrogenesis


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Related to fibrogenesis: fibrosis, fibrose

fi·bro·gen·e·sis

(fī'brō-jen'ĕ-sis),
The production or development of fibers.

fibrogenesis

The synthesis of “fibrous” tissue, including collagen and elastic fibres.
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Chen, "Curcumin protects the rat liver from C[Cl.sub.4]-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation," Molecular Pharmacology, vol.
Previously, we demonstrated that hypoxia promoted hepatic fibrogenesis through the regulation of PPAR[gamma] in vitro.
Lario et al., "O153 the farnesoid X receptor agonist, obeticholic acid, improves intestinal antibacterial defense and reduces gut bacterial translocation and hepatic fibrogenesis in CCl4-cirrhotic rats with ascites," Journal of Hepatology, vol.
This study has attempted to elucidate the role of ACKR1 polymorphism in liver fibrosis progression of HCV infection, but our results demonstrated that ACKR1 polymorphism is not directly associated with the fibrogenesis in HCV positive patients by using non-invasive serum liver related markers.
Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration.
Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis. Gut 44(4):534-541, 1999.
Smith et al., "Serum markers of hepatic fibrogenesis in cystic fibrosis liver disease," Journal of Hepatology, vol.
As histone modifications are implicated in the progression of kidney fibrosis, several HDAC, HAT, and HMT inhibitors are currently being advanced for the management of DKD, which could attenuate fibrogenesis. Hence, it is imperative to understand the consequences of variations in histone lysine acetylation and methylation, in order to explore novel biomarkers and therapeutic directions for DKD.
PAI-1 expression is elevated under pathologic fibrotic conditions, which contributes to a reduced rate of fibrinolysis and subsequent decrease in degradation of ECM components, including FN, resulting in tissue fibrogenesis [22].
During fibrogenesis, excessive connective tissue accumulates in the liver and results in the distortion of hepatic architecture [1].