In contrast, none of the 44 cases (0%) of the fibroepithelial neoplasms, including 10 FAs and 34 PTs, were reactive.
In 2013, Cimino-Mathews et al (164) studied 99 invasive breast CAs and 34 fibroepithelial neoplasms and found GATA3 expression in 67% (66 of 99) of the breast CAs and stromal GATA3 labeling in only 1 of 34 fibroepithelial neoplasms (3%); the positive rate was 43% in triple-negative tumors and 54% in MCAs.
Although CNB can provide high negative and positive predictive values, accurate diagnosis based on a limited sample from CNBs can sometimes be challenging for fibroepithelial neoplasms because of the heterogeneity and overlapping features in these lesions.
Misdiagnosis of these 2 entities may occur because of the heterogeneity of PTs or some overlapping features between the fibroepithelial neoplasms.
Although IGF1 and IGF2 overexpression may be important in the pathogenesis of fibroepithelial neoplasms of the breast, these markers may not be useful in differentiating fibroadenomas from PTs.
3-6) Phyllodes tumor is a rare fibroepithelial neoplasm accounting for less than 1% of all breast tumors and approximately 2.