fibroblast growth factors


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fibroblast growth factors

A family of peptide regulators produced by virtually all cells. Their range of actions is wide. Only some are stimulators of the collagen-producing cells, the fibroblasts. Other effects include strong stimulation of vascular endothelial cell proliferation. Some are produced in relatively large quantities by brain tumours. Hope for people paralysed by spinal cord injuries has been raised by the discovery that a measure of rejoining in severed spinal cord tracts in rats can be achieved using a fibrin ‘glue’ containing a fibroblast growth factor. A mutation in the gene for a fibroblast growth factor receptor can cause CRANIOSYOSTOSIS.
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The fact that mast cells have the ability to release fibroblast growth factors and heparin-binding epidermal growth factors (as well as to stimulate these in nearby fibroblasts) is significant because it illustrates the intrinsic relationship between mast cells and ECM-producing fibroblasts.
The fibroblast growth factor receptor (FGFR) family is composed of four members, FGFR1/2/3/4, which are activated by interacting with fibroblast growth factors (FGFs), resulting in the activation of downstream signaling pathways including mitogen-activated protein kinase signal transducer and activator of transcription and PI3K/ Akt/mTOR signaling (1,2).
According to the company's R&D EVP, Dr Ornitz is an internationally recognized expert in fibroblast growth factors, its receptors and a variety of other interacting signaling pathways, growth factors and is an Alumni Endowed Professor at Washington University School of Medicine.
Some of David's research centers on examining fibroblast growth factors, its receptors, and a variety of other interacting signaling pathways.
Fibroblast growth factors (FGFs) are implicated in pregnancy success by regulating embryogenesis, implantation, and placentation through cell survival, migration, and differentiation (25).
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.
The probable mechanism for the reduced number of ERC's is through inhibition of the expression of fibroblast growth factors in neural crest cells.
Fibroblast Growth Factors: Biology and Clinical Application: FGF Biology and Therapeutics
Wrathall, "Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury," European Journal of Neuroscience, vol.
Fibroblast growth factors and their receptors in the central nervous system.
Fibroblast growth factors (FGFs) are a large family of structurally-related, widely expressed, multifunctionalheparin-binding polypeptides, which contain 23 members in vertebrates.
With more than 20 family members, fibroblast growth factors (FGFs) (4) generally influence cell division and survival involving the differentiation and development of tissues, healing, and neoplasia.

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