fibrinolysis

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fibrinolysis

 [fi″brĭ-nol´ĭ-sis]
the dissolution of fibrin by enzymatic action. adj. adj fibrinolyt´ic.
Fibrinolysis. From Copstead, 1995.

fi·bri·nol·y·sis

(fī-bri-nol'i-sis), Avoid the mispronunciation fibronoly'sis.
1. Hydrolysis of fibrin.
2. The process of dissolution of fibrin in blood clots.
[fibrino- + G. lysis, dissolution]

fibrinolysis

/fi·bri·nol·y·sis/ (fi″brin-ol´ĭ-sis) dissolution of fibrin by enzymatic action.fibrinolyt´ic

fibrinolysis

(fī′brə-nŏl′ĭ-sĭs)
n. pl. fibrinoly·ses (-sēz′)
The breakdown of fibrin, usually by the enzymatic action of plasmin.

fi′bri·no·lyt′ic (-nə-lĭt′ĭk) adj.

fibrinolysis

[fī′brinol′isis]
the process of fibrin digestion by plasmin that is the normal mechanism for the removal of fibrin clots. It is stimulated by adhesion of plasmin and tissue plasminogen activator to fibrin. fibrinolytic, adj.

fi·bri·nol·y·sis

(fī'bri-nol'i-sis)
Hydrolysis of fibrin.
[fibrino- + G. lysis, dissolution]

fibrinolysis

The use of drugs to dissolve blood clots in the circulation. Enzymes such as streptokinase or urokinase, which break down FIBRIN, are used. A combination of fibrinolysis and aspirin, given soon after a coronary attack, greatly improves the chances of survival.

Fibrinolysis

The clot dissolving portion of the coagulation process.
Mentioned in: Fibrin Split Products

fi·bri·nol·y·sis

(fī'bri-nol'i-sis)
Hydrolysis of fibrin.
[fibrino- + G. lysis, dissolution]

fibrinolysis

the dissolution of fibrin by enzymatic action.

pathological fibrinolysis
see primary fibrinolysis (below).
primary fibrinolysis
occurs with an excess of activators or decreased plasma inhibitors that cause hyperplasminemia, as in severe liver disease, heat stroke and malignancy.
secondary fibrinolysis
is a response to the widespread formation of microthrombi as in disseminated intravascular coagulation.
References in periodicals archive ?
Only 58% of eligible patients received fibrinolytic agents within 12 hours.
Interhospital transfer delays, while clearly problematic, could be mitigated if fibrinolytic agents were rapidly administered at the receiving hospital.
The latter findings in our study also call for immediate attention and should serve to encourage the development of written protocols at referring institutions to assure a most expedite clinical assessment of patients, the enhancement of those institutions for utilizing fibrinolytic agents in suitable candidates and the timely referral to PCI-capable facilities of those patients that are still within the time frame for beneficial results from catheter-based reperfusion.
Patient demographic and clinical characteristics included sociodemographic variables (gender, age); medical history (hypertension, diabetes, dyslipidemia); the admission time of day (day, evening, or night); and admission day of week (weekday or weekend), the presence of chest pain, the location of myocardial infarction, the fibrinolytic agent used, the percentages of post-fibrinolytic TIMI-3 flow, and post-fibrinolytic CABG.
Both groups had similar ages and similar percentages of men, hypertension, diabetes, dyslipidemia, chest pain, and anterior wall infarctions on presentation, the use of streptokinase as the fibrinolytic agent, and similar percentages of TIMI-3 flow restoration, and the need for coronary artery bypass grafting.
Therefore, genotyping of this polymorphism may become relevant to risk assessment and to the selection and dosing of patients being treated with anticoagulant and fibrinolytic agents, in particular with tissue plasminogen activator.
Thrombolysis with various fibrinolytic agents has been described in cases with occluded shunts, as an alternative or adjuvant therapy to balloon angioplasty.