fibrillarin


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fibrillarin

(fī″bril′ă-rin, fib″ril′) [ fibrillar + -in]
A structural protein found within the cytoskeleton of the nucleolus of eukaryotic cells. Antibodies against this protein are found in some patients with scleroderma, esp. patients with diffuse involvement of the skin.
References in periodicals archive ?
1997), and modification of the nucleolar antigen fibrillarin from a 34-kDa non-disulfide-bonded form to a 32-kDa disulfide-bonded form.
1996) demonstrated that antibodies to fibrillarin and chromatin tended to persist several months following cessation of mercuric chloride treatment, whereas anti-histone antibodies resolved more rapidly.
Autoantibodies to fibrillarin in systemic sclerosis (scleroderma).
1994), which have been related to the presence of antibodies to fibrillarin (Pollard et al.
The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties.
Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity.