Two iron transport proteins, divalent metal transporter 1 (DMT1) and
ferroportin 1 (FPN), are expressed in duodenal enterocytes [4, 5].
However, the iron from different states such as absorbed iron in duodenal enterocytes or stored within hepatocytes or recycled by macrophages; ultimately pass from cytoplasm of cells to the transferrin (Ganz et al., 2012), and iron efflux from cells is facilitated via a multipass transmembrane protein i.e., iron exporter
ferroportin 1 (Donovan et al., 2005).
Theurl et al., "Expression of the duodenal iron transporters divalent-metal transporter 1 and
ferroportin 1 in iron deficiency and iron overload," Gastroenterology, vol.
This association between the levels of lead and iron is likely due to their sharing of the same transporters, such as the divalent metal transporter 1 (DMT1) and
ferroportin 1 (FP1).
Tfr2[beta] levels were evaluated, together with the main proteins involved in cellular iron traffic, namely, the iron deposit protein ferritin (Ft-L), the iron importer DMT1, and the iron exporter
Ferroportin 1 (Fpn1).
Hepcidin is also considered as a master regulator in the management of cellular iron homeostasis by binding to iron exporter protein
ferroportin 1 (Fpn1) in cell membranes and causing its subsequent internalization and lysosomal degradation [3].
Functional consequences of
ferroportin 1 mutations.
In the cell, iron is reduced to the ferric form and exported to the blood by
ferroportin 1 [solute carrier family 40 (iron-regulated transporter), member 1; SLC40A1, formerly FPN1] at the basolateral membrane.
pylori infection and resulted in the upregulation of the expression of various downstream iron absorption and efflux genes such as
Ferroportin 1, Divalent metal transporter 1, and Transferrin receptor 1 [35].
The identification of
ferroportin 1 B may explain how high ferroportin expression is possible in duodenal epithelial and erythroid precursor cells during high intracellular iron levels.
Iron overloading and erythrophagocytosis increase
ferroportin 1 (FPN1) expression in J774 macrophages.
Novel mutation in
ferroportin 1 gene is associated with autosomal dominant iron overload.
