Fc receptor

(redirected from Fc-receptor)

Fc re·cep·tor

receptors present on a variety of cells for the Fc fragment of immunoglobulins. These receptors recognize immunoglobulins of the IgG and IgE class.

Fc receptor

A receptor on phagocytes (neutrophils, monocytes, and macrophages) that binds Fc fragments of immunoglobulins G and E.
See: immunoglobulin; macrophage processing; phagocytosis
See also: receptor


1. a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing some effect in the cell, e.g. the cell-surface receptors of immunocompetent cells that recognize antigens, complement components or lymphokines, or those of neurons and target organs that recognize neurotransmitters or hormones; see also opioid receptors.
2. a sensory nerve ending that responds to various stimuli, e.g. arterial stretch, baroreceptors, cold, Golgi tendon organs, joint, muscle and tendon, olfactory, retinal, taste and warmth.

receptor activation
the cell of a sensory receptor responds to a specific energy change in its environment and initiates a corresponding sensory input.
adrenergic r's
receptors for epinephrine or norepinephrine, such as those on effector organs innervated by postganglionic adrenergic fibers of the sympathetic nervous system. Classified as α-adrenergic receptors, which are stimulated by norepinephrine, and β-adrenergic receptors, which are stimulated by epinephrine. See also adrenergic receptors.
autonomic r's
includes adrenergic and muscarinic receptors.
cholinergic r's
receptor sites on effector organs innervated by cholinergic nerve fibers and which respond to the acetylcholine secreted by these fibers. There are two types: muscarinic receptors and nicotinic receptors.
complement receptor
a cell-surface receptor capable of binding activated complement components. For example, component C3b is bound to neutrophils, B lymphocytes and macrophages.
dopamine r's
there are dopamine-inhibitory and dopamine-excitatory receptors.
drug receptor
a component of tissue with which a drug reacts. Classified according to the type of drugs that react with them.
Fc receptor
bind immunoglobulins via Fc part of the molecule.
histamine r's
receptors for histamine, classified as H1-receptors, which produce bronchoconstriction and contraction of the gut and are blocked by antihistamines, such as mepyramine or chlorpheniramine, and H2-receptors, which produce gastric acid secretion and are blocked by H2-receptor blockers, such as cimetidine.
muscarinic receptor
see muscarinic receptors.
nicotinic receptor
see nicotinic receptors.
peripheral receptor
sensory receptors including cutaneous warm and cold, dermoreceptors touch and pain plus receptors in the mucosae.
sensory receptor
an endorgan at the end of an afferent neuron which is capable of stimulation by a specific change, physical or chemical, in the internal or external environment of the patient.
toll-like r's
a family of transmembrane proteins that differentially recognize pathogen-associated molecular patterns through an extra cellular domain and initiate inflammatory signaling pathways through an intracellular domain; they play a central role in the innate immune response to pathogens.
receptor tyrosine kinases
a large class of cell-surface receptors with tyrosine-specific protein kinase activity.
References in periodicals archive ?
Proteinase-activated receptor-2 up-regulation by Fc-receptor activation in human neutrophils.
Unlike the Fc-engineered existing anti-CD3 antibodies which can still activate T cells, resulting in mild cytokine release syndrome, coltelizumab does not contain the Fc fragment, without any Fc-receptor binding activity.
Daha, "Transforming growth factor-beta 1 (TGF-[beta]1) down-regulates IgA Fc-receptor (CD89) expression on human monocytes," Clinical and Experimental Immunology, vol.
After SRBC stimulus, the production of macrophage NO was lower than LPS and this may be correlated to less engulfment or FC-receptor non-stimulation.
Although human Fc-receptor cell lines may be convenient for assaying DENV antibodies, decisions regarding their use should be deferred until they are shown to model primary myeloid cells.
Histamine changes the phenotype of lymphocytes (CD4 + to CD8 +) and rises Fc-receptor activity, T-lymphocytes can strengthen biosynthesis of histamine and its secretion through interleukins.
TCDD (high dose) and DEX (both doses) up-regulated an Fc-receptor gene associated with antigen binding and a small group of histocompatibility genes associated with antigen presentation.
Purchased research and development amounted to a charge to earnings of $3,952,000 for the year ended June 30, 1998 as a result of the Company's acquisition of the Fc-Receptor Technology and the Thrombospondin Technology in November 1997.
That many HA2-specific antibodies do not display substantial antiviral activities in vitro does not preclude protective activity in vivo because the mere binding of antibody to native HA expressed on infected cells and infectious virus could mediate protective activity by targeting Fc-receptor expressing cells or complement deposition to these structures.
In Fiscal Year 1998, the Company incurred a one-time charge to earnings of $3,952,000 for purchased research and development as a result of the Company's acquisition of the Fc-Receptor Technology and the Thrombospondin Technology.
In 1997, the Company incurred a one-time charge to earnings of $3,880,000 for purchased research and development as a result of the Company's acquisition of the Fc-Receptor Technology and the Thrombospondin Technology.
Additionally, we have made good preclinical progress with our Thrombospondin technology which may prove useful in preventing the spread of cancer and our Fc-receptor technology program which may be useful in treating asthma/allergy and infection.