Dr Karin Enell Smith, senior scientist Preclinical Development at Alligator Bioscience, will give an oral presentation with the title 'ATOR-1017 - A tumour directed Fc-receptor
cross-linking dependent 4-1BB agonistic antibody at 15:30 hours EDT on 21 June 2018.
Proteinase-activated receptor-2 up-regulation by Fc-receptor
activation in human neutrophils.
The effects of different concentrations of IVIG on phytohemagglutinin (PHA) activated T lymphocytes were examined in vitro , and it was observed that IVIg controls the T lymphocyte activation, possibly by binding to the specific Fc-receptor
expressed on the surface of activated T cells.
Unlike the Fc-engineered existing anti-CD3 antibodies which can still activate T cells, resulting in mild cytokine release syndrome, coltelizumab does not contain the Fc fragment, without any Fc-receptor
Agrawal, "Immunoglobulin IgG Fc-receptor
polymorphisms and HLA class II molecules in Guillain-Barre syndrome," Acta Neurologica Scandinavica, vol.
After SRBC stimulus, the production of macrophage NO was lower than LPS and this may be correlated to less engulfment or FC-receptor
Although human Fc-receptor
cell lines may be convenient for assaying DENV antibodies, decisions regarding their use should be deferred until they are shown to model primary myeloid cells.
Histamine changes the phenotype of lymphocytes (CD4 + to CD8 +) and rises Fc-receptor
activity, T-lymphocytes can strengthen biosynthesis of histamine and its secretion through interleukins.
TCDD (high dose) and DEX (both doses) up-regulated an Fc-receptor
gene associated with antigen binding and a small group of histocompatibility genes associated with antigen presentation.
That many HA2-specific antibodies do not display substantial antiviral activities in vitro does not preclude protective activity in vivo because the mere binding of antibody to native HA expressed on infected cells and infectious virus could mediate protective activity by targeting Fc-receptor
expressing cells or complement deposition to these structures.
Daha, "Transforming growth factor-beta 1 (TGF-[beta]1) down-regulates IgA Fc-receptor
(CD89) expression on human monocytes," Clinical and Experimental Immunology, vol.
Some researchers have surmised that, as with DENV, when antibody-virus complexes attach to Fc-receptors
, viruses are brought close to cell surfaces, where they enter the cells by normal mechanisms (31,32).