Fc receptors

Fc receptors

Cell surface receptors of a specific chemical ‘shape’ to bind to the Fc heavy chain terminals of the appropriate classes of immunoglobulin molecules (antibodies). IgE molecules, for instance, bind to the Fc receptors on MAST CELLS and blood eosinophil cells. IgG molecules bind to Fc receptors on phagocyte cell membranes.
References in periodicals archive ?
M230, a selective immunomodulator of Fc receptors and the multiple Fc domains of ICs aggregate Fc?
Nonneutralizing antibodies do not directly interfere with TNF binding but may compromise therapeutic efficacy by contributing to enhanced clearance of the drug from the circulation through immune complex formation and binding to Fc receptors on phagocytic cells (14).
In one report, a B cell-deficient mouse was used to show NETs could not be formed, thus suggesting a direct role for Fc receptors in this function [23].
The effects of intravenous immunoglobulin include complex mechanisms, but it exerts its essential action by eliminating the non-specific Fc receptors found in the mononuclear phagocytic system or by inhibiting binding of immune complexes to Fc receptors in the cells.
However, those bioassays generally show high variability, due primarily to both variable expression of Fc receptors and inherent genetic variability of these receptors between donors (mAbs 2012 4:p310).
Unlike IgG, IgY antibodies do not bind to bacterial Fc receptors, such as staphylococcal protein A or streptococcal protein G (JENSENIUS et al.
The engulfment percentage was significant with opsonized SRBC and VE treatment; this might be due to strengthening of FC receptors.
arms of the antigen presentation pathway, major histocompatibility (MHC) I (B2m) and MHC II (CD74, HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1) molecules, and three Fc receptors.
Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of high avidity and high frequency helper and CTL responses.
Potential sites for Syk in RA include: Fc receptors on mast cells, dendritic cells, macrophages, and neutrophils; the B-cell receptor; and potentially sites through osteoclast receptors.
The IVIG also blocks the Fc receptors in the spleen and macrophages, thereby limiting their platelet-destroying function.