Fc receptors

Fc receptors

Cell surface receptors of a specific chemical ‘shape’ to bind to the Fc heavy chain terminals of the appropriate classes of immunoglobulin molecules (antibodies). IgE molecules, for instance, bind to the Fc receptors on MAST CELLS and blood eosinophil cells. IgG molecules bind to Fc receptors on phagocyte cell membranes.
References in periodicals archive ?
mAb depend on their Fc region for function, triggering immune responses following engagement of Fc receptors on immune effector cells.
The Fc receptors of IgG (a link between humoral and cellular immunological responses), are highly interested in the etiology and pathogenesis of autoimmune diseases and Fc gamma receptors are encoded in the long arm of chromosome 1 (4, 5).
TTI-622 consists of the same CD47-binding domain of human SIRPa as TTI-621 but linked to an IgG4 Fc region, which has a more restricted ability to engage activating Fc receptors. It is expected to have a different pharmacologic profile than TTI-621 and is being developed primarily for combination therapy.
Ravetch, "Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets," Nature Medicine, vol.
M230, a selective immunomodulator of Fc receptors and the multiple Fc domains of ICs aggregate Fc?
Hellman, "Fc receptors for immunoglobulins and their appearance during vertebrate evolution," PLoS One, vol.
The best characterized and maybe most important opsonic phagocytic receptors are the Fc receptors (FcR) and the complement receptors (CR).
Nonneutralizing antibodies do not directly interfere with TNF binding but may compromise therapeutic efficacy by contributing to enhanced clearance of the drug from the circulation through immune complex formation and binding to Fc receptors on phagocytic cells (14).
The new mouse model incorporated the human versions of both the CD40 protein and Fc receptors, a group of proteins expressed on immune cells.
The effects of intravenous immunoglobulin include complex mechanisms, but it exerts its essential action by eliminating the non-specific Fc receptors found in the mononuclear phagocytic system or by inhibiting binding of immune complexes to Fc receptors in the cells.
Additional functional variation exists as a result of the differential affinities and cellular expression that occurs within the family of Fc receptors and their variants.
Unlike IgG, IgY antibodies do not bind to bacterial Fc receptors, such as staphylococcal protein A or streptococcal protein G (JENSENIUS et al., 1981).