Fc receptor

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Related to Fc receptor: Complement receptor, ADCC

Fc re·cep·tor

receptors present on a variety of cells for the Fc fragment of immunoglobulins. These receptors recognize immunoglobulins of the IgG and IgE class.

Fc receptor

A receptor on phagocytes (neutrophils, monocytes, and macrophages) that binds Fc fragments of immunoglobulins G and E.
See: immunoglobulin; macrophage processing; phagocytosis
See also: receptor


1. a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing some effect in the cell, e.g. the cell-surface receptors of immunocompetent cells that recognize antigens, complement components or lymphokines, or those of neurons and target organs that recognize neurotransmitters or hormones; see also opioid receptors.
2. a sensory nerve ending that responds to various stimuli, e.g. arterial stretch, baroreceptors, cold, Golgi tendon organs, joint, muscle and tendon, olfactory, retinal, taste and warmth.

receptor activation
the cell of a sensory receptor responds to a specific energy change in its environment and initiates a corresponding sensory input.
adrenergic r's
receptors for epinephrine or norepinephrine, such as those on effector organs innervated by postganglionic adrenergic fibers of the sympathetic nervous system. Classified as α-adrenergic receptors, which are stimulated by norepinephrine, and β-adrenergic receptors, which are stimulated by epinephrine. See also adrenergic receptors.
autonomic r's
includes adrenergic and muscarinic receptors.
cholinergic r's
receptor sites on effector organs innervated by cholinergic nerve fibers and which respond to the acetylcholine secreted by these fibers. There are two types: muscarinic receptors and nicotinic receptors.
complement receptor
a cell-surface receptor capable of binding activated complement components. For example, component C3b is bound to neutrophils, B lymphocytes and macrophages.
dopamine r's
there are dopamine-inhibitory and dopamine-excitatory receptors.
drug receptor
a component of tissue with which a drug reacts. Classified according to the type of drugs that react with them.
Fc receptor
bind immunoglobulins via Fc part of the molecule.
histamine r's
receptors for histamine, classified as H1-receptors, which produce bronchoconstriction and contraction of the gut and are blocked by antihistamines, such as mepyramine or chlorpheniramine, and H2-receptors, which produce gastric acid secretion and are blocked by H2-receptor blockers, such as cimetidine.
muscarinic receptor
see muscarinic receptors.
nicotinic receptor
see nicotinic receptors.
peripheral receptor
sensory receptors including cutaneous warm and cold, dermoreceptors touch and pain plus receptors in the mucosae.
sensory receptor
an endorgan at the end of an afferent neuron which is capable of stimulation by a specific change, physical or chemical, in the internal or external environment of the patient.
toll-like r's
a family of transmembrane proteins that differentially recognize pathogen-associated molecular patterns through an extra cellular domain and initiate inflammatory signaling pathways through an intracellular domain; they play a central role in the innate immune response to pathogens.
receptor tyrosine kinases
a large class of cell-surface receptors with tyrosine-specific protein kinase activity.
References in periodicals archive ?
Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand.
Other signaling molecules that are important for Fc receptor signaling via ITAM are Syk and PI-3K.
In addition, inhibition of the Fc receptor is likely shut down the release of other damaging chemicals that are triggered with TNFa.
The human IgA Fc receptor (CD89) is expressed on various myeloid cells and has been previously shown to mediate antigen uptake, processing, and even presentation of defined antigens [15, 17, 19-21].
The EMA draft guidance recommends testing biosimilars for their binding to the Fc receptor FcRn.
There is no evidence that the A face of CRP can bind C1q and an Fc receptor simultaneously, so what is it that controls whether CRP binds C1q or engages an Fc receptor?
Human antibody -- Fc receptor interactions iluminated by cristal structures.
Antigenic variation of varicella zoster virus Fc receptor gE: loss of a major B cell epitope in the ectodomain.
PRIMABioMed Limited (Melbourne, Australia), the cancer and immunotherapy research and therapeutic development company, announced that it has received notification from the United States Patent and Trademark Office that it will allow an application relating to the three dimensional (3D) structure of the Fc receptor (FcR), the target of drugs being developed by its subsidiary Arthron Ltd.
CBT-502 has a comparable efficacy profile in in-vitro and in-vivo studies to marketed anti-PD-L1 antibodies and has a no Fc receptor activity.
In contrast, other B cell signaling defects may cause up-regulated signaling, as exemplified by the loss of inhibitory Fc receptor function.
CBP-1011 is a compound derived from the Fc receptor technology which is currently being used in a Phase III clinical trial for ITP, and Phase II trials for the treatment of inflammatory bowel disease.