Fc fragment


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Related to Fc fragment: Surface immunoglobulin

Fc frag·ment

the crystallizable fragment of an immunoglobulin molecule composed of the constant regions of the heavy chains and responsible for binding to antibody receptors (Fc receptor) on cells and the Clq component of complement.
Synonym(s): Fc piece

Fc frag·ment

, Fc (frag'mĕnt)
The crystallizable fragment of an immunoglobulin molecule composed of part of the heavy chains and responsible for binding to antibody receptors on cells and the Clq component of complement.

Fc fragment

A small piece of an immunoglobulin (an antibody) used by macrophages in processing and presenting foreign antigens to T lymphocytes.
See: immune response; macrophage processing

Fc fragment

a portion of an immunoglobulin molecule, produced by papain digestion, with parts of two heavy chains. It has no antigen-combining sites, but contributes to a number of effector functions such as the binding of antibody to Fc receptors on a variety of cells, the transfer of antibody from the circulation into colostrum, the transfer across the gut of the newborn, and the binding of complement.
References in periodicals archive ?
Ravetch has further shown that these anti-inflammatory properties can be reproduced with sFc, a fully recombinant preparation of appropriately sialylated IgG Fc fragments, providing a more efficacious and potent treatment at lower dose levels.
15) removal of Fc fragment or after addition of 15 mg/L native MAK33 or 15 mg/L heat-aggregated MAK33 II Results normalized after 269 3.
2] fragment of ~112 kDa and a Fc fragment of 36 kDa (two parts of 18 kDa each).
Available sera from those patients were frozen and thawed and rechecked manually with (a) basic buffer (the screening assay); (b) basic buffer plus 15 mg/L native murine monoclonal MAK33 added; (c) basic buffer plus 15 mg/L heat-treated MAK33; (d) the Fc fragment removed plus basic buffer; (e) the Fc fragment removed plus basic buffer plus 15 mg/L native MAK33; and (f) Fc fragment removed plus basic buffer plus 15 mg/L heat-treated MAK33 (the reference assay).
For type III samples, removal of the Fc fragment normalized CEA concentrations, but not the addition of 15 mg/L heat-treated murine monoclonal MAK33.
Removing the Fc fragment from the capture antibody as the only measure nearly eliminated interference.
A second choice is to reduce interference by removing the Fc fragment (29) or by changing the structure of (32, 33) or chemically modifying (34) the assay antibodies.
Heat-treated nonspecific murine immunoglobulin in the buffer and removal of the Fc fragment from the capture antibody both by themselves reduce interference in immunometric assays.
15) removal of Fc fragment or after addition of 15 mg-L native MAK33 or 15 mg-L heat-treated MAK33 Type II Results normalized after 148 3.
Briefly, Balb/c mice (8-12 weeks of age) were immunized with four intraperitoneal injections of Fc fragments of IgG myeloma proteins emulsified in Freund's complete adjuvant (Sigma, USA) (first injection) or incomplete adjuvant (Sigma, USA) (other injections) (50 [micro]g, every 2 weeks).
Balb/c mice (8-12 weeks of age) were immunized with four intraperitoneal injections of Fc fragments of human IgG 1 or IgG2 myeloma proteins emulsified in Freund's complete adjuvant (Sigma, USA) (first injection) or incomplete adjuvant (Sigma) (other injections) (50 [micro]g every 2 weeks).