ALDH3A2

(redirected from Fatty aldehyde dehydrogenase)

ALDH3A2

A gene on chromosome 17p11.2 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH3A2 gene product catalyses the oxidation of long-chain aliphatic aldehydes to fatty acid.

Molecular pathology
ALDH3A2 mutation causes Sjögren-Larsson syndrome.
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References in periodicals archive ?
Sjogren-Larsson syndrome (SLS) is a rare neurocutaneous disorder caused by deficient activity of fatty aldehyde dehydrogenase (FALDH) and is characterized by congenital ichthyosis, spastic diplegia or tetraplegia, and intellectual disability.
It is caused by deficient activity of fatty aldehyde dehydrogenase (FALDH), a component of the fatty alcohol nicotinamide adenine dinucleotide (NAD) oxidoreductase enzyme complex (FAO).
Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol: NAD+ oxidoreductase in cultured fibroblasts," Journal of Clinical Investigation, vol.
Human liver fatty aldehyde dehydrogenase: microsomal localization purification and biochemical characterization.
Studies by Rizzo and coworkers (3-5) have identified the enzyme that is deficient in SLS as fatty aldehyde dehydrogenase (FALDH; EC 1.2.1.3), which is encoded by the ALDH10 gene.
Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:[NAD.sup.+] oxidoreductase in cultured fibroblasts.