Synthesis and antitumor activity of an inhibitor of fatty acid synthase
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Abbreviations: TG, trigonelline; PPAR[gamma], peroxisome proliferator-activated receptor-[gamma]; C/EBP-[alpha], CCAAT element binding protein-[alpha]; aP2, adipocyte fatty acid binding protein; GLUT-4, glucose transporter-4; cAMP, cyclic adenosine monophosphate; C/EBP-[delta], CCAAT element binding protein-[delta]; C/EBP-[BETA], CCAAT element binding protein-[beta]; FAS, fatty acid synthase
; WST, 2(2-methoxy-4-nitrophenyl)-3(4-nitrophenyl)-5- (2,4-disulfophenyl; DMEM, Dulbecco modified Eagle medium; FBS, fetal bovine serum; 1BMX, 3-isobutyl- l -methylxanthine; DEX, dexamethasone; RXR, retinoid X receptor; LPL, lipoprotein lipase; ATCC, American Type Culture Collection.
Many drug makers are focusing on inhibitors of fatty acid synthase
because they are known to block the conversion of carbohydrates into fat and suppress appetite as well as slow the growth of cancer cells.
Effect of bovine fatty acid synthase
, stearoyl-coenzyme a desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle.
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase
Hormonal regulation of mouse fatty acid synthase
gene transcription in liver.
Article: Porcine fatty acid synthase
gene polymorphisms are associated with meat quality and fatty acid composition.
Moreover, its deletion leads to alterations in the expression levels of genes involved in lipid and carbohydrate metabolism, PPARG, AQP7, or fatty acid synthase
(Rahib et al., 2007).
Recent studies demonstrated that inhibition of SCD catalytic activity reduced the activities of genes associated with de novo fatty acid synthesis, such as fatty acid synthase
while increasing expression of genes associated with fatty acid oxidation, such as CPT1[beta] (Kim et al., 2011; Kadegowda et al., 2013).
No difference was observed in hepatic fatty acid synthase
(FASN) expression between bulls and steers.
Knockout studies have reported THRSP null mice to show a marked deficiency in de novo lipogenesis and revealed that the THRSP may work in the cytoplasm by tethering the fatty acid synthase
to the microtubule (Lafave et al., 2006).