Table 1 List of various pro-apoptotic and anti-apoptotic factors involved in the sepsis Pro-apoptotic factors Anti-apoptotic factors BAX Bcl-2 Bcl-xs Bcl-xl, Bcl-Al BIM, PUMA, NOXA Inhibitor of apoptosis proteins FAS ligand
Mcl-1 Tumour necrosis factor- a Ras factor- a BID, BAK Apoptosis-inducing factor p53 BAX=Bcl-2-associated X protein, Bcl=B cell lymphoma, BIM=Bcl-2-interacting moderator of cell death, PUMA=p53- upregulated modulator of apoptosis, NOXA=phorbol-12 myristate-l-acetate-induced protein, FAS=cell surface Fas receptor also known as CD95L, Mcl=M cell lymphoma, Ras=rat sarcoma, BID=BH3 interacting death domain, BAK=Bcl-2 homologous antagonist killer.
2 months from 8 treatment naive HIV infected individuals were also available for the estimation of soluble Fas antigen and Fas ligand.
Plasma soluble Fas antigen and soluble Fas ligand were estimated by commercial ELISA (MBL, Nagoya, Japan).
Role of Fas ligand
(CD95L) in immune escape: the tumor cell strikes back.
According to the recent study, the phony version of Fas receptors on the cancer cells binds with Fas ligand
, preventing it from hooking up with real Fas receptors and from starting the apoptosis cascade, researchers report in the Dec.
expression in the lymph nodes of HIV-infected patients was comparable to that in reactive lymph nodes of the controls.
Poster #57: Functional Fas ligand
is expressed on human cutaneous T-cell lymphoma cells and inhibited by bexarotene.
The cell-death-inducing Fas ligand
(FasL) has also emerged in another arena.
Some guardian lymphocytes, particularly T cells, wield a molecule called Fas ligand
(FasL) against outlaw cells.
Recent studies with others demonstrated that Sertoli cells also can kill activated T cells by programmed cell death, or apoptosis, through interaction with the Fas ligand
Instead, the tissues appear to produce a molecule, known as Fas ligand
, that kills immune cells approaching with destructive intent.
After Fas ligands
or anti-Fas antibodies (ARG098, etc.