farnesyl pyrophosphate

(redirected from Farnesylpyrophosphate)

far·nes·yl py·ro·phos·phate

(far'nĕ-sil pī'rō-fos'fāt),
The pyrophosphoryl derivative of farnesol; a key intermediate in the synthesis of steroids, dolichol, ubiquinone, prenylated proteins, and heme a.
References in periodicals archive ?
Such isoprenoid intermediates are inclusive of geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP), which are part of the cholesterol biosynthetic pathway.
By inhibiting the rate-limiting enzyme in the cholesterol biosynthesis pathway (conversion of hydroxymethylglutaryl CoA to mevalonate), they also prevent the formation of isoprenoid intermediaries like isopentenyl-pyrophosphate, dimethylallyl-pyrophosphate, geranyl-pyrophosphate, and farnesylpyrophosphate. Isoprenoids play an important role in the posttranslational modification and membrane attachment of multiple signaling molecules, among them GTP-binding proteins of the Ras and Rho family.
The inhibition of the enzyme HMG-CoA reductase, an essential key in the biosynthesis of cholesterol (Medina 2010; Musso et al., 2011), demonstrates to be the key point to reduce cholesterol and several compounds like isopentenyladenine, dolichol, ubiquinone, geranilpirofosfato (GGPP), farnesylpyrophosphate (FPP) (Wong et al., 2007; Gauthaman et al., 2009).