prenylation

(redirected from Farnesylation)

pre·nyl·a·tion

(pre'nil-ā'shŭn),
The covalent addition of prenyl and multiprenyl residues to a macromolecule.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
LaminB1 also undergoes some forms of post-translational modifications, such as farnesylation [29], phosphorylation, glycosylation, and sumoylation [30], which are linked to the significant conformational changes of their target proteins [31].
Differential Expression of LaminB1 in the Developing Rat Cochlea
Lonafarnib blocks the farnesylation of progerin and has been dosed in over 80 children with Progeria at Boston Children's Hospital in Phase 1/2 and Phase 2 studies funded by The Progeria Research Foundation.
Clinigen Partners with Eiger BioPharmaceuticals to Launch Worldwide Managed Access Programme for Lonafarnib for Patients with Progeria and Progeroid Laminopathies
Lonafarnib blocks the farnesylation of progerin and has been dosed in over 80 children at Boston's Children Hospital in Phase 1/2 and Phase 2 studies.
Eiger awarded US FDA's breakthrough therapy designation for lonafarnib for the treatment of Progeria and progeroid laminopathies
Tipifarnib is an inhibitor of farnesylation, a key cell signalling process implicated in cancer initiation and resistance to standard therapies.
Kura Oncology, OncoDNA announces screening collaboration
A hypothesis on the mechanism of inhibition in anticancer activity indicates that SQ reduces the activity of the HMG-CoA reductase enzyme by limiting the steps towards normal cholesterol synthesis and intermediate stages where geranyl diphosphate (GDP) and farnesyl diphosphate (FDP) produce important substrates for the biosynthesis of ubiquinones and for the prenylation (farnesylation) of proteins.
Plant Sources, Extraction Methods, and Uses of Squalene
Kondo et al., "C-terminal farnesylation of UCH-L1 plays a role in transport of Epstein-Barr virus primary oncoprotein LMP1 to exosomes," mSphere, vol.
Deubiquitinating Enzymes and Bone Remodeling
Since isoprenoids, such as geranylgeranyl pyrophosphate and farnesyl pyrophosphate, are able to revert rosuvastatin effect on PAI-1 expression, protein geranylation or/and farnesylation could be one involved mechanism [69].
Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue
Kirschmeier, "The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling.
Placental Ras Regulates Inflammation Associated with Maternal Obesity
Molecular tailoring of farnesylation for plant drought tolerance and yield protection.
PHLOEM PROMOTERS IN TRANSGENIC SWEET ORANGE ARE DIFFERENTIALLY TRIGGERED BY Candidatus Liberibacter asiaticus/PROMOTORES DE FLOEMA SAO DIFERENTEMENTE ATIVADOS POR Candidatus Liberibacter asiaticus EM LARANJEIRAS DOCES TRANSGENICAS
In in vitro studies of inhibition by DHEA of protein geranylation and farnesylation (together referred to as protein isoprenylation), we had demonstrated that the block to protein isoprenylation could be relieved by the addition of the isoprene donor geraniol [6, 7].
Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition
Lu, "Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways," Oncotarget, vol.
Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway
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