prenylation

(redirected from Farnesylation)

pre·nyl·a·tion

(pre'nil-ā'shŭn),

The covalent addition of prenyl and multiprenyl residues to a macromolecule.

References in periodicals archive ?

Molecular tailoring of farnesylation for plant drought tolerance and yield protection.

PHLOEM PROMOTERS IN TRANSGENIC SWEET ORANGE ARE DIFFERENTIALLY TRIGGERED BY Candidatus Liberibacter asiaticus/PROMOTORES DE FLOEMA SAO DIFERENTEMENTE ATIVADOS POR Candidatus Liberibacter asiaticus EM LARANJEIRAS DOCES TRANSGENICAS

Tipifarnib is an inhibitor of farnesylation, a key cell signaling process implicated in cancer initiation and development, and is under investigation in multiple ongoing clinical trials.

United States : Kura Oncology establishes collaboration with Foundation Medicine to support Tipifarnib Development in HRAS mutant head and neck cancer

Pex19p is 33-kDa farnesylated protein harboring farnesylation CAAX box motif and localized mostly in the cytosol and only partly anchored to peroxisomal membranes.

Peroxisome biogenesis and human peroxisome-deficiency disorders

The product is an inhibitor of farnesylation, a major cell signalling process implicated in cancer initiation and development.

Kura Oncology starts dosing in Phase II clinical trial of tipifarnib

The company's lead programme, tipifarnib, is an inhibitor of farnesylation, a key cell signaling process implicated in cancer initiation and development.

US Drugmaker Kura Oncology Completes Reverse Merger with Zeta Acquisition

Rheb belongs to the Ras family, which encodes a carboxyl-terminal CAAX box, suggesting that the protein undergoes posttranslational farnesylation--the membrane localization of Rheb through farnesylation is important for upstream regulation of mTOR signaling (Basso et al.

Direct interaction between Ras homolog enriched in brain and FK506 binding protein 38 in cashmere goat fetal fibroblast cells

PRL-3 molecule contains C-terminal consensus sequence for prenylation (CAAX motif) which is responsible for farnesylation of the protein.

Detection of PRL-3 protein in the preoperative serum of patients with colorectal cancer

Induction of the Cholesterol Metabolic Pathway Regulates the Farnesylation of RAS in Embryonic Chick Heart Cells: A New Role for Ras in Regulating the expression of Muscarinie Receptors and G proteins", The Embo Journal.

Effects of statin drugs on atherosclerosis and cardiovascular disease due to reductase inhibition and nutrient depletions

A clinical review showed that the pathway of modifications in the processing of prelamina through alterations in farnesylation offers a possible drug target21.

KISSCHILD WITH STUNTED GROWTH, BALD HEAD AND BIRD LIKE FACIES

Molecularly, bisphosphonates block farnesyl diphosphate (FPP) synthase, an enzyme required in the production of cholesterol, farnesylation, and geranyl-geranylation.

Metastatic lesions of the proximal femur

It targets the farnesylation pathway upstream at the level of farnesyl diphosphate synthase.

Morphogenomics and morphoproteomics: a role for anatomic pathology in personalized medicine

Major post-translational modifications like phosphorylation, acetylation, ribosylation, methylation, farnesylation, etc.