Molecular tailoring of farnesylation
for plant drought tolerance and yield protection.
Tipifarnib is an inhibitor of farnesylation
, a key cell signaling process implicated in cancer initiation and development, and is under investigation in multiple ongoing clinical trials.
Pex19p is 33-kDa farnesylated protein harboring farnesylation
CAAX box motif and localized mostly in the cytosol and only partly anchored to peroxisomal membranes.
The product is an inhibitor of farnesylation
, a major cell signalling process implicated in cancer initiation and development.
The company's lead programme, tipifarnib, is an inhibitor of farnesylation
, a key cell signaling process implicated in cancer initiation and development.
Rheb belongs to the Ras family, which encodes a carboxyl-terminal CAAX box, suggesting that the protein undergoes posttranslational farnesylation
--the membrane localization of Rheb through farnesylation
is important for upstream regulation of mTOR signaling (Basso et al.
PRL-3 molecule contains C-terminal consensus sequence for prenylation (CAAX motif) which is responsible for farnesylation
of the protein.
Induction of the Cholesterol Metabolic Pathway Regulates the Farnesylation
of RAS in Embryonic Chick Heart Cells: A New Role for Ras in Regulating the expression of Muscarinie Receptors and G proteins", The Embo Journal.
A clinical review showed that the pathway of modifications in the processing of prelamina through alterations in farnesylation
offers a possible drug target21.
Molecularly, bisphosphonates block farnesyl diphosphate (FPP) synthase, an enzyme required in the production of cholesterol, farnesylation
, and geranyl-geranylation.
It targets the farnesylation
pathway upstream at the level of farnesyl diphosphate synthase.
Major post-translational modifications like phosphorylation, acetylation, ribosylation, methylation, farnesylation