Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate
synthase activity in Escherichia coli.
Sen et al., "Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate
synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones," Proteins, vol.
Molecularly, bisphosphonates block farnesyl diphosphate
(FPP) synthase, an enzyme required in the production of cholesterol, farnesylation, and geranyl-geranylation.
(19) This process is due to the inhibition of the enzyme farnesyl diphosphate
synthase, (20,21) especially by the administration of nitrogen-containing bisphosphonates, such as alendronate.
It targets the farnesylation pathway upstream at the level of farnesyl diphosphate
Ramas-Valdivia and colleagues (55) discovered the enzyme farnesyl diphosphate
synthase from T.
Genes coding for proteins involved in cholesterol biosynthesis and [beta]-oxidation appeared consistently regulated by the treatment (i.e., mitochondrial CPT1, acyl-CoA thioester hydrolase, 3-hydroxy-3-methylglutamyl-CoA (HMG-CoA) reductase, squalene epoxidase, farnesyl diphosphate
(FPP)-transferase, FPP-synthase were upregulated, while acyl-CoA desaturase, acyl-CoA synthetase, and acyl-CoA oxidase 2 were downregulated) (Ratra et al 1998b).