Curvilinear Profile

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A typical finding in Farber’s disease, a glycosphingolipidosis, consisting of comma-shaped tubular rods within vacuoles of histiocytes, seen by EM
DiffDx Cytoplasmic inclusions in peripheral lymphocytes, skin fibroblasts in juvenile lipofuscinosis—Batten-Mayou-Spielmeyer-Vogt disease—amaurotic familial idiocy, Batten’s disease, Kufs disease, Jansky-Bielschowsky syndrome, Spielmeyer-Vogt disease
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