Famvir


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famciclovir

Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA)

Pharmacologic class: Synthetic nucleoside

Therapeutic class: Antiviral

Pregnancy risk category B

Action

Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis

Availability

Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

Acute herpes zoster infection (shingles)

Adults: 500 mg P.O. q 8 hours for 7 days

Recurrent genital herpes in immunocompetent patients

Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear

Suppression of recurrent genital herpes

Adults: 250 mg P.O. b.i.d. for up to 1 year

Recurrent herpes simplex infection in patients with human immunodeficiency virus

Adults: 500 mg P.O. b.i.d. for 7 days

Herpes labialis (oral herpes simplex) in immunocompetent patients

Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 18.

Administration

• Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions.

• Give with or without food.

Adverse reactions

CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia

EENT: pharyngitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia

Musculoskeletal: back pain, joint pain

Skin: pruritus, rash

Other: fever

Interactions

Drug-drug. Digoxin: increased digoxin blood level, increased risk of toxicity

Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir)

Patient monitoring

• When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity.

• Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels.

• Be aware that drug may take several weeks to reach therapeutic level.

• Know that renal failure may raise blood drug level, increasing the risk of adverse reactions.

• Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact.

Patient teaching

• Instruct patient to take with food or milk to avoid upset stomach.

• Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming.

• Advise patient to wear loose-fitting clothing to avoid irritating lesions.

• Tell patient to report rash or itching.

• Instruct female patient to tell prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Famvir

(făm′vîr′)
A trademark for the drug famciclovir.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Famvir

A brand name for FAMCICLOVIR.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The company obtained marketing approval for Famvir (Generic name: famciclovir) in Japan, where it has been distributed under license by Maruho for the indication of herpes zoster (shingles) since July 2008.
For the most recent 12 months ending December 2010, Famvir and its generics recorded total US sales of approximately USD197m, according to IMS Health data.
Tyring receives research funding and is on the speakers bureau for Novartis, which makes Famvir, and Glaxo-SmithKline, which makes Valtrex.
Tyring receives research funding from and is on the speakers' bureaus for Novar-tis and GlaxoSmithKline, the respective manufacturers of Famvir and Valtrex.
won approval for its generic version of Novartis AG's Famvir herpes treatment.
She was started on famciclovir (Famvir) and given a prescription for hydrocodone with acetaminophen (Vicodin).
Famciclovir (Famvir) is a daily antiviral pill prescribed to limit herpes outbreaks.
There was no difference in side effects between patients using Famvir and placebo patients in the study that led to approval of the genital herpes indication, said Dr.
Famvir significantly reduced the time to healing of non-aborted lesions, as well as time to resolution of studied symptoms in RGH patients with lesions by almost two days.
Antiviral drugs such as famciclovir (Famvir) are used with mixed results.
Prescription antiviral medicines--including Zovirax (acyclovir), Famvir (famciclovir), and Valtrex (valacyclovir)--may help speed healing and reduce shingles pain if taken within the first 72 hours of symptoms.
Traditional prescription medications to prevent and treat cold sores include Acyclovir (Zovirax), valacyclovir (Valtrex), and famcyclovir (Famvir).