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Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA)

Pharmacologic class: Synthetic nucleoside

Therapeutic class: Antiviral

Pregnancy risk category B


Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis


Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

Acute herpes zoster infection (shingles)

Adults: 500 mg P.O. q 8 hours for 7 days

Recurrent genital herpes in immunocompetent patients

Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear

Suppression of recurrent genital herpes

Adults: 250 mg P.O. b.i.d. for up to 1 year

Recurrent herpes simplex infection in patients with human immunodeficiency virus

Adults: 500 mg P.O. b.i.d. for 7 days

Herpes labialis (oral herpes simplex) in immunocompetent patients

Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear

Dosage adjustment

• Renal impairment


• Hypersensitivity to drug or its components


Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 18.


• Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions.

• Give with or without food.

Adverse reactions

CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia

EENT: pharyngitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia

Musculoskeletal: back pain, joint pain

Skin: pruritus, rash

Other: fever


Drug-drug. Digoxin: increased digoxin blood level, increased risk of toxicity

Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir)

Patient monitoring

• When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity.

• Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels.

• Be aware that drug may take several weeks to reach therapeutic level.

• Know that renal failure may raise blood drug level, increasing the risk of adverse reactions.

• Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact.

Patient teaching

• Instruct patient to take with food or milk to avoid upset stomach.

• Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming.

• Advise patient to wear loose-fitting clothing to avoid irritating lesions.

• Tell patient to report rash or itching.

• Instruct female patient to tell prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.


A trademark for the drug famciclovir.


a trademark for an antiviral drug (famciclovir).


A brand name for FAMCICLOVIR.
References in periodicals archive ?
The company obtained marketing approval for Famvir (Generic name: famciclovir) in Japan, where it has been distributed under license by Maruho for the indication of herpes zoster (shingles) since July 2008.
For the most recent 12 months ending December 2010, Famvir and its generics recorded total US sales of approximately USD197m, according to IMS Health data.
Comment: In the multinational study of 329 immunocompetent adults who had had at least four genital herpes outbreaks within the previous year, the benefits of 1 day of Famvir 1,000 mg b.
The new data demonstrates that Famvir can minimize a recurrent genital herpes outbreak, and stop symptoms such as pain and burning, in a median of less than a day.
The firms offered to divest, by means of a licensing agreement, Famvir in the European Economic Area (EEA), which will remove the entire overlap between Glaxo Wellcome and SmithKline Beecham.
Recent antiviral drugs, Valtrex and Famvir, are absorbed very quickly and seem to halt progression of the condition.
Although such antiviral drugs as Zovirax, Valtrex, and Famvir may shorten an attack, they do not eliminate the infection.
Comment: In the multinational study of 329 immunocompetent adults, the benefits of 1 day of Famvir 1,000 mg b.
Announcements for divestitures of the most high-profile drugs were made months ago when the firms agreed to divest SmithKline's antiviral medicines Famvir and Vectavir, along with Kytril for treating chemotherapy-induced nausea.
They are the generic equivalent of Famvir (Novartis AG).
What is the dose of Famvir to treat a primary (not recurrent) herpes genital infection?