factor V Leiden

(redirected from Factor V Leiden thrombophilia)

factor V Leiden

(lī'den),
variant of the protein factor V (5), a clotting factor. Factor V Leiden gene is present in 3% of the general population. People who carry the factor V Leiden gene have a fivefold greater risk of thrombosis than the rest of the population. The factor V mutation (factor V Leiden) is the most common genetic cause of venous thrombosis. The factor V Leiden mutation causes resistance to activated protein C, yielding a defect in the natural anticoagulation system.

factor V Leiden

Hematology A variant of factor V present in 3%-8% of Caucasians associated with a ↑ risk of DVT. See LETS, Hereditary thrombophilia.
References in periodicals archive ?
(7.) Cruz-Amy M, Hunter-Mellado R: Factor V Leiden thrombophilia: presentation of three patients and a literature review.
Autosomal-dominant inheritance of the prothrombin gene mutation in a Puerto Rican family: a case study
My daughter recently convinced me to have my first genetic test, after she tested positive for factor V Leiden thrombophilia, a risk factor for blood clotting disorder.
Direct-to-consumer genetic tests and the right to know
Factor V Leiden thrombophilia. Available from http://www.genectinics.org/profiles/factor-v-leiden/detaits.html.
Factor V Leiden: an overview
Factor V Leiden thrombophilia. Genet Med 2011;13(1):1-16.
Prevalence of 1691G>A FV mutation in Poland compared with that in other Central, Eastern and South-Eastern European countries
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