factor V Leiden

(redirected from Factor V Leiden thrombophilia)

factor V Leiden

(lī'den),

variant of the protein factor V (5), a clotting factor. Factor V Leiden gene is present in 3% of the general population. People who carry the factor V Leiden gene have a fivefold greater risk of thrombosis than the rest of the population. The factor V mutation (factor V Leiden) is the most common genetic cause of venous thrombosis. The factor V Leiden mutation causes resistance to activated protein C, yielding a defect in the natural anticoagulation system.

factor V Leiden

Hematology A variant of factor V present in 3%-8% of Caucasians associated with a ↑ risk of DVT. See LETS, Hereditary thrombophilia.

References in periodicals archive ?

My daughter recently convinced me to have my first genetic test, after she tested positive for factor V Leiden thrombophilia, a risk factor for blood clotting disorder.

Even in the medical arena, if my doctor had not agreed to test for factor V Leiden thrombophilia, I would have liked the option of ordering the test myself.