FGD1(redirected from FYVE, RhoGEF and PH domain containing 1)
FGD1A gene on chromosome p11.21, which encodes a protein that contains Dbl and pleckstrin homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen-activated protein-kinase cascade, leading to c-Jun kinase SAPK/JNK1 activation.
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