FZR1

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FZR1

A gene on chromosome 19p13.3 that encodes a key regulator of ligase activity of the anaphase-promoting complex/cyclosome (APC/C), conferring substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis (in place of CDC20) and activates the APC/C during anaphase and telophase. The APC/C degrades the substrate to ensure that cell cycle upregulators do not accumulate prematurely; at the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. FZR1 is highly expressed in the heart, liver, spleen, and in some cancer cell lines.
References in periodicals archive ?
The post FYR Macedonia's main opposition party rejects proposal for new country name appeared first on Cyprus Mail .
The agency said that more than 7,000 people had reached Serbia overnight Saturday-Sunday after managing to cross from Greece to FYR Macedonia and take a train at the town of Gevgelija.
The takeover will see Fyr Fyter's two founders - Brian Hogg and Paul Bainbridge - support PHS during a handover period before exiting to pursue other interests.
Armenia vs Slovakia; Republic of Ireland vs Russia; Andorra vs FYR Macedonia
Goals from Toto Tamuz and Roberto Colautti either side of half-time handed the visitors a second win in four days ( the first a 2-1 victory over FYR Macedonia in Skopje.
1968: Alan Mullery - England 0Yugoslavia 1 (European Championship finals) 1973: Alan Ball - Poland 2 England 0 (World Cup qualifier 1977: Trevor Cherry - Argentina 1 England 1 (friendly 1986: Ray Wilkins - England 0 Morocco 0 (World Cup finals1998: David Beckham - England 2Argentina 2 (World Cup finals) 1998: Paul Ince - Sweden 2 England 1 (European Championship qualifier1999: Paul Scholes - England 0 Sweden 0 (European Championship qualifier1999: David Batty - Poland 0 England 0 (European Championship qualifier) 2002: Alan Smith - England 2 FYR Macedonia 2 (European Championship qualifier2005: David Beckham - England v Austria (World Cup qualifier
Unless he appeals and is successful, van Nistelrooy will miss Holland's first two 2006 World Cup qualifying matches - at home to the Czech Republic on September 8 and FYR Macedonia away on October 9.
At Oksoy fyr in Vest-Agder, Norway, there was a total of 184.3 mm of rain in May, two and half times as much as normal according to meteorologists.
The European Investment Bank (EIB), the European Union's financing institution, and the Government of the Former Yugoslav Republic of Macedonia have signed a Framework Agreement which will enable the country to access the Bank's lending resources to support sound investment in a large spectrum of productive sectors, including transports, energy, environmental protection, telecommunications, as well as industry, tourism and services.After a Financial Protocol attached to the Co-operation and Transport Agreement between the European Commission and FYR of Macedonia came into force in January 1998, the EIB mainly supported FYROM's transport sector, with a total of Euro 130 million for two road projects.
The EBRD is a leading investor in the six Western Balkans countries: Serbia, Montenegro, Albania, FYR Macedonia, Kosovo and Bosnia and Herzegovina, with average annual commitments of 1 billion and a leading force in policy engagement.
The building stock in the FYR Macedonia is in urgent need of refurbishment and the introduction of new technologies such as insulation is expected to lower costs and improve comfort.