FVIII


Also found in: Acronyms.

FVIII

a large glycoprotein containing more than 2300 amino acids, 24 cysteine residues, and 25 potential glycosylation sites. The factor is used to treat blood-clotting disorders, such as hemophilia A, in which the factor is deficient or missing. Also called recombinant factor VIII concentrate.
References in periodicals archive ?
7 (16), using the tridimensional model of the crystal structure of FVIII available at the Protein Data Bank (17, 18) (PDB ID: 2R7E).
Rarer diseases include fibrinogen deficiency, prothrombin (FII) deficiency, FV deficiency, combined FV and FVIII deficiency, FVII deficiency, FX deficiency, FXI deficiency and FXIII deficiency.
Se diagnostica cuando hay sangrado despues de haber colocado el FVIII y se detecta por medio de una prueba de laboratorio denominada Bethesda, segun la cual, >5 unidades representan una respuesta alta y <5 unidades una respuesta baja (17).
The oncotic pressure values and FVIII values are presented in Table-III.
In the presence of vWF, half-life of FVIII is about 12 hours, (78) while without it, the half-life decreases to about 2 hours.
Whole blood count, peripheral blood smear, blood group, serum transaminases, urea, creatinine, ferritin, PFA-100, PT, aPTT, INR, TT, fibrinogen, VWF:Ag, VWF:RCo, FVIII, and platelet aggregation assays were performed.
Characterization of minor bands of STR amplification reaction of FVIII gene by PCR cloning.
FVIII and FIX mutation analysis should be done in all patients with haemophilia A and B, especially newly diagnosed patients (grade B, level IIb).
Further, Inspiration has initiated a second pivotal clinical trial in individuals with congenital hemophilia A who have developed inhibitors against human FVIII.