FUT3


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FUT3

A gene on chromosome 19q13.3 that encodes a fucosyltransferase with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities, which catalyses the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. 

Molecular pathology
FUT3 mutations are responsible for most Lewis antigen-negative blood group phenotypes.
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Bombay blood group 211100 FUT1 or FUT2 Para-Bombay blood group 211100 FUT1 Non-secretor blood group 182100 FUT2 Lewis-negative blood group 111100 FUT3 CDG-IIc 266265 FUCT1 CDG-IId 607091 B4GALT1 CDG-IIe 608779 COG7 CMRD 246700 SARA2 Anderson disease 607689 SARA2 CMRD with Marinesco--Sjogren syndrome 607692 SARA2 A.
Molecular basis for Lewis all/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees.
Influence of Lewis [alpha]1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping and circulating tumor marker sialyl-Lewis a levels.
Influence of Lewis a(1,3/1,4)-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping and circulating tumor marker sialyl-Lewis a levels.