FUS


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FUS

A gene on chromosome 16p11.2 that encodes a multifunctional protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, which is involved in pre-mRNA splicing and export of processed mRNA to the cytoplasm. FUS belongs to the FET family of RNA-binding proteins that regulate gene expression, maintain genomic integrity and process mRNA/microRNA processing.

Molecular pathology
FUS mutations cause amyotrophic lateral sclerosis type 6; a FUS/CHOP translocation (t(12;16)(q13;p11)) leads to the formation of a chimeric protein, which induces liposarcoma.
References in periodicals archive ?
Fus Hields, who has a four-year-old son, was treated in hospital for his wound but volunteered to return to operational duty at the earliest opportunity.
L'article Coupes d'Afrique: WAC et FUS en mission difficile mais pas impossible est apparu en premier sur ALBAYANE .
From the beginning, the sector was dominated by business and investment groups, with the biggest, Bilkent Holding, Sabanci Holding, and Koc Holding, establishing the first FUs in the wake of the 1983 legislation.
Sharing the structural and functional properties with TDP-43, FUS is a 526-amino acid protein containing a prion-like, low-complexity domain that is enriched with glutamine, glycine, serine, and tyrosine (Q/G/S/Y) residues [35, 88], followed by a nuclear export signal, a RNA recognition motif (RRM) domain, arginine/glycine- (R/G-) rich domains, and a zinc-finger motif and nuclear localization signal (Figure 1).
A good candidate for FUS is diagnosed by a movement disorder neurologist and has moderate to severe postural or intention tremor of their dominant hand ([greater than or equal to] 2 on the Clinical Rating Scale for Tremor [CRST]).
Of the 1,084 patients who presented to the Uvea unit of the Ulucanlar Eye Hospital, the medical records of the 161 patients (14.8%) diagnosed with FUS were analyzed retrospectively.
MLS/RCLS carry a rearranged DDIT3 fused to FUS or EWSR1 [5, 6].
After extraction, these FUs were palced in the recipient site according to the pre-operative plan.
Should immunostains show ubiquitin- or p62-positive inclusions that are TDP-43 negative, or no tau- or ubiquitin-positive inclusions at all, an additional immunostain can be considered, using an antibody to FUS (also known as FUS/TLS, fused in sarcoma/translocated in liposarcoma protein).
Therapeutic high intensity focused ultrasound (HIFU) or Focused Ultrasound (FUS) is a noninvasive medical treatment that allows the deposition of energy inside the human body.
The approach was used with transiently transfected human cells that ectopically express the FUS (5) (fused in sarcoma) gene.
The following are just some of the young men from the West Midlands area who gave their lives in Korea: Rfn Samuel F Plant, L/Col Samuel J Bunce, Gnr Stephen Foy, Fus Stanley Ludlow, Ptel Louis Whitmore, L/Cpl Reginald A Smith, 2nd Lt John A Godfrey, Fus Francis H Roberts, Pte Frederick Gill, Sgt Sidney M Cox.