FURIN


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FURIN

A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R consensus motif. Furin releases albumin, complement C3 and vWF from their respective precursors.

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor. After transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
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References in periodicals archive ?
Thus, the results showed that Sema3C significantly inhibited the formation of a microcapillary network of HUVEC; however, this activity was lost upon R745A mutation, indicating that the C-terminal arginine of the putative furin cleavage site at the basic domain of Sema3C protein was critical for its functions in angiogenesis process.
The release of F49A is achieved by furin cleavage (3), and the protein synthesis is inhibited by PE, leading to (4) killing of the human cytomegalovirus (HCMV) infected cells.
Another similarity between Patiria miniata (Pm) Vtg2 and chicken Vtg2 is the presence of two more furin proteolytic cleavage sites in the C-terminus, although the cleavage sites of P.
A second example of a Sindbis virus structural protein mutant able to organize into nonnative structures is that of the furin mutants in the glycoproteins E1 and E2 shown in Figure 7 [53].
G Jonsson (Chair), N Davies, C Freeman, J Joska, S Pahad, R Thorn, K Thompson, N Woollett (Panel Members), J Furin, G Meintjes (Reviewers)
This exists in tissues, generally in a latent and inactive form, bound to the latency-associated peptide (LAP), and it is activated through proteolytic cleavage by thrombospondin, plasmin, cathepsin D, furin, and glycosidases when exposed to PD solutions [21].
[section] 401 and proposing a statutory amendment that would eliminate restrictive conditions imposed by Congress on DoD HCA activities and clarify the meaning of "military operations"); Major Timothy Austin Furin, Legally Funding Military Support to Stability, Security, Transition, and Reconstruction Operations, ARMY LAW., Oct.
What has prevailed is a public pedagogy liberated from the confines of school buildings, making the community at large an indispensable classroom (Furin, 2007).
Here HPAI viruses differ from LPAI viruses in cellular proteases as ubiquitous furin and PC 6 (proprotein convertases) are essential for cleavage of HA of HPAI viruses while HA of LPAIV is cleaved only by trypsin-like proteases secreted from cells in respiratory and intestinal tracts (Klenk and Garten, 1994; Swayne and Suarez, 2000).
The G1 arginine to histidine change at amino acid residue 87 in exon 1 substitutes one basic charged polar group with another and occurs at a position before the furin cleavage site for the mature peptide, so is unlikely to affect the activity of the mature protein (Hanrahan et al., 2004).