FTA-ABS test


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Related to FTA-ABS test: VDRL test, treponemal antibody

fluorescent

 [floo͡-res´ent]
pertaining to or characterized by fluorescence.
fluorescent antibody test a test for the distribution of cells expressing a specific protein by binding antibody specific for the protein and detecting complexes by fluorescent labeling of the antibody. Called also FAB test.
fluorescent treponemal antibody absorption test the standard treponemal antigen test for syphilis: Nonspecific antibodies are removed from patient serum, which is then reacted with Treponema pallidum fixed to a glass slide. Specific antibodies adhering to the treponemes are demonstrated with fluorescein-labeled antihuman globulin. Positive tests are seen in about 85 per cent of cases of primary syphilis, 100 per cent in secondary syphilis, and 98 per cent in late syphilis. The test remains positive for life even after syphilis has been successfully treated. Called also FTA-ABS test.

fluor·es·cent trep·o·ne·mal an·ti·bod·y-ab·sorp·tion test

a sensitive and specific serologic test for syphilis using a suspension of the Nichols strain of Treponema pallidum as antigen; the presence or absence of antibody in the patient's serum is indicated by an indirect fluorescent antibody technique.
Synonym(s): FTA-ABS test

FTA-ABS test

The fluorescent treponemal antibody-absorbed test. This is a sensitive test for SYPHILIS which it can demonstrate even if the disease is latent.
References in periodicals archive ?
Laboratory Results IHC Results 1 RPR test nonreactive Positive FTA-ABS test reactive Tpallidum qualitative real-time PCR positive HIV test positive 2 RPR test reactive Positive FTA-ABS test reactive HIV test unknown 3 RPR test reactive Positive TP-PA test reactive HIV test unknown 4 RPR test reactive Positive Syphilis treponemal antibody positive HIV test positive Abbreviations: FTA-ABS, fluorescent treponemal antibody absorption; HIV, human immunodeficiency virus;IHC, immunohistochemistry; MSM, men who have sex with men; PCR, polymerase chain reaction; RPR, rapid plasma reagin; TP-PA, Treponema pallidum particle agglutination.
([paragraph][paragraph]) FTA-ABS test was used as the confirmatory treponemal test.
To evaluate reverse sequence screening in populations with high and low syphilis prevalence and to evaluate the use of TP-PA and FTA-ABS tests for identifying false-positive EIA/CIA screening tests, CDC analyzed syphilis screening data from five clinical laboratories.
For each site and overall, the following percentages were calculated: 1) reactive EIA/CIAs among all sera, 2) discordant sera among those with reactive EIA/CIAs (i.e., those with negative nontreponemal test results), and 3) nonreactive confirmatory TP-PA or FTA-ABS tests among discordant sera.
The overall sensitivity of RPR to detect primary syphilis in our setting was 69.3% and its specificity was 86.1%, while the sensitivity and specificity of the FTA-ABS test were 89.6% and 58.5% respectively.
As has been demonstrated previously in southern Africa, the utility of both treponemal and non-treponemal serological tests for the diagnosis of primary syphilis is questionable, (16) since many patients with primary syphilis are seronegative (especially by the RPR test), while others with ulcerations caused by other organisms are seropositive (especially by the FTA-ABS test) as a result of previously treated treponemal infections.
Among the many serologic tests available, the RPR test and FTA-ABS test are the most widely employed.
[11] The greater sensitivity of the FTA-ABS test does not improve detection when the tests are used serially.
Comparison with TPI and FTA-ABS tests. Br J Vene dis 1972;48(6):470-3.