Brauner, "Evaluation of the fluorescent treponemal antibody-absorption (FTA-Abs
) test specificity," Acta Dermato-Venereologica, vol.
Apos a realizacao dos testes treponemicos de FTA-ABS
, a incidencia de anticorpos antitreponemicos na populacao estudada foi de 4,49 casos para cada 1000 habitantes.
(3,9) Due to their increased specificity and sensitivity, the treponemal assays Treponema pallidum particle agglutination assay (TPPA), the FTA-ABS
assay, and ELISA are used mainly as diagnosis confirmation tools.
The screening test can sometimes have false-positive results, so we need confirmatory tests, and they are used if any screening test is positive: Treponemal EIA, FTA-abs
KEY WORDS: Syphilis, Treponema Pallidum infection, Recurrent miscarriages, VDRL, FTA-ABS
His laboratory investigations including erythrocyte sedimentation rate (ESR), angiotensin converting enzyme (ACE), Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody absorption test (FTA-ABS
), chest radiograph, antinuclear antibodies (ANA) and HIV serology were carried out.
Examples of syphilis serologic tests (adapted from the CDC) (9) Manual Automated Direct Darkfield or contrast microscopy or direct fluorescent antibody stains -- Nontreponemal (IgG and IgM VDRL RPR -- against lipoidal cellular antigens) Treponemal (IgG and/or IgM TP-PA FTA-ABS
Immunoassay (IA) against T.
Fluorescent Treponemal Antibody test (FTA)/Fluorescent Treponemal Antibody Absorption (FTAABS): Due to the disadvantages outlined above, the TPI was largely replaced by FTA-ABS
of India, Kolkata), Treponema pallidum haemagglutination assay (Plasmatec TPHA test kit, Hansard Diagnostics, United Kingdom) in VDRL reactive cases and fluorescent treponemal antibody absorption (FTA-ABS
) test using FTA-Abs
IgG and IgM IFA (Viro-Immun Labor-Diagnostika Gmbh, Oberursel & Virgo, Calbiotec, USA) in sera giving discrepant results in the above two tests were carried out.
Among these discordant sera, 31.6% also were nonreactive by treponemal testing using Treponema pallidum particle agglutination (TP-PA) or fluorescent treponemal antibody absorbed (FTA-ABS
"The CSF-VDRL might be nonreactive even when neurosyphilis is present; therefore, additional evaluation using FTA-ABS
[fluorescent treponemal antibody absorbed] testing on CSF can be considered.