S100A4

(redirected from FSP1)
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S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
A protein called fibroblast-specific protein 1 (FSP1) has long been considered to be a reliable indicator of fibroblasts in injured organs undergoing tissue remodeling and has been broadly used to identify the presence of fibrotic disease.
The new research undermines the validity of prevailing assumptions about EMT and FSP1, but also opens the door to new avenues of investigation that could ultimately lead to improved detection and treatment of cirrhosis and similar conditions.
"The old evidence and assumptions about the source of fibroblasts and the role of FSP1 as a marker are not valid," he added.
Likewise, experiments proved FSP1 to be an unreliable marker for fibrosis.
Similarly, FSP1 was determined not to be a marker for myofibroblasts (a fibroblast with some properties of a smooth muscle cell) or any precursors of myofibroblasts.