FSHR


Also found in: Acronyms.

FSHR

A gene on chromosome 2p21-p16 that encodes a G protein-coupled receptor for follicle stimulating hormone, which plays a key role in gonad development.

Molecular pathology
FSHR mutations cause ovarian dysgenesis type 1 and ovarian hyperstimulation syndrome.
References in periodicals archive ?
CHO cell lines stably transfected with human FSHR have been described previously (Bonomi et al.
De Filippo et al., "FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women," European Journal of Endocrinology, vol.
The expression of genes related to folliculogenesis (FIGLA, KIT-L, GDF9 and FSHR) was evaluated using real-time RT- PCR before and after two weeks of in vitro culture period.
Conversely, the relative abundance of FSHR mRNA was increased at 72 h in the E2 treated group (P < 0.001).
Because 3' UTR sequences of porcine CYP19A1 and FSHR genes have not been reported, we aligned the 3' flanking sequences of these two genes with the respective human 3' UTR sequences to get the consensus sequences for further prediction.
Based on our present results and previous results mentioned above, we propose a possible functional mechanism of LHR in meiotic regulation: FSH induced LHR expression increases and the newly synthesized LHRs forms heterodimers with other G proteins (such as FSHRs) coexpressed in cumulus cells, resulting in the activation of the ERK1/2 MAPK signaling pathway, and then the oocyte resumes meiosis.
ABSTRACT: In order to understand the molecular mechanism of heterosis of reproduction traits in chickens, we used the quantitative real-time reverse transcriptional polymerase chain reaction (Quantitative real-time RT-PCR) technique to investigate the differential expression of estrogen receptor (ESR) and follicle stimulating hormone receptor (FSHR) genes in 32-week-old ovaries of inbred chickens and their hybrid offspring in 4 x 4 diallel crosses, which involved White Plymouth Rock (E), CAU Brown (D), Silkies (C) and White Leghorn (A).
ABSTRACT: Effects of daidzein on expression of mRNAs of gonadotropin receptors (FSHR, LHR) and P450 aromatase (P450arom) were evaluated in ovarian follicles of white silky fowls.
FSH mediates its function by binding to its receptor, FSHR, located on the surface of granulosa cells within the follicles , which generates different signals inside the cell to control the function and fate of the growing ovarian follicle.
FSH exerts its functions via binding to its cognate receptor (FSHR) expressed in ovarian cancers and gynecologic malignancies (1).