FSHR

(redirected from FSH receptor)

FSHR

A gene on chromosome 2p21-p16 that encodes a G protein-coupled receptor for follicle stimulating hormone, which plays a key role in gonad development.

Molecular pathology
FSHR mutations cause ovarian dysgenesis type 1 and ovarian hyperstimulation syndrome.
References in periodicals archive ?
FSH receptor binding inhibitor-8 (FRBI-8), a non-steroidal antagonist for FSH, was identified from sheep and human ovarian follicular fluid (12,13).
FSH receptor is expressed in Sertoli cells, which support germ cells during multiple stages of spermatogenesis.
DE-T1 can significantly upregulate the expression of the estrogen receptor in the uterus and FSH receptor (FSHR) in the ovaries of mice and increase the secretion of estradiol (E2).
De Leener classified spontaneous OHSS syndrome into three types based on clinical presentation and FSH receptor mutation.
Monoclonal Antibody Conjugate to Agonize FSH Receptor for Women Infertility - Drug Profile 126
Preliminary data on large cohorts of samples revealed genetic biomarkers linked to spontaneous ovulation for PCOS patients, efficacy of low molecular weight heparin for the prevention of spontaneouse abortion, specific allells of FSH receptor linked with OHSS or poor response to controlled ovarian hyperstimulation.
FSH receptor (FSHR) is a glycosylated transmembrane protein belonging to the family of G-protein-coupled receptors.
One of the possible causes is a mutation in the FSH receptor gene.
LH-induced WNT signaling has been observed in rodent ovaries, particularly with increased expression of WNT4 and Fzd-1 (20) Correspondingly, conditional knock-out of WNT4 in mouse ovaries significantly reduced FSH receptor expression and [P.sub.4] levels in hormonally stimulated mice (29) Collectively, these data may suggest that WNT molecules regulate GC maturation and differentiation through a variety of molecular pathways and in a [beta]-catenin-independent manner; however, these hypotheses will require further clarification.
The FSH receptor (FSHR) is a plasma membrane receptor that, along with the LH/ hCG receptor, belongs to the G protein-coupled receptor (GPCR) superfamily (Minegishi et al.
The authors showed that osteoclastogenic and proresorptive actions of FSH are exerted through a [G.sub.i2[alpha]]-coupled FSH receptor (FSHR) that has been identified on both human and mouse osteoclast and their precursors [12].