FRS2

(redirected from FRS2A)

FRS2

A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating  PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.
References in periodicals archive ?
demonstrated that FGF/fibroblast growth factor receptor substrate 2A (FRS2A)/Grb2/SHP2 axis was responsible for NSCs proliferation but not differentiation [54].
Gotoh, "FRS2a is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus," in Yearbook of Pediatric Endocrinology, J.-C.
Liu et al., "FRS2a is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts," International Journal of Biological Sciences, vol.