FRS2A | definition of FRS2A by Medical dictionary
FRS2 (redirected from FRS2A)
FRS2 A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.
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References in periodicals archive
demonstrated that FGF/fibroblast growth factor receptor substrate 2A (FRS2A
)/Grb2/SHP2 axis was responsible for NSCs proliferation but not differentiation .
is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus," in Yearbook of Pediatric Endocrinology, J.-C.
Liu et al., "FRS2a
is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts," International Journal of Biological Sciences, vol.