FOXP2


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FOXP2

A gene on chromosome 7q31 that encodes a member of the forkhead/winged-helix family of transcription factors, which is expressed in foetal and adult brain, lung and gut. It is evolutionarily conserved, and binds hundreds of different gene promoters to regulate the expression of their cognate genes. FOXP2 is required for proper development of speech and language areas of the brain during embryogenesis, and is involved in pathways that influence language development.

Molecular pathology
FOXP2 mutations cause speech-language disorder type 1 (autosomal dominant speech and language disorder with orofacial dyspraxia).
References in periodicals archive ?
Summary: TEHRAN (FNA)- FOXP2, a gene implicated in affecting speech and language, is held up as a textbook example of positive selection on a human-specific trait.
Wolfgang Enard of Ludwig-Maximilians University Munich in Germany, showed that mice are better at learning if they have the human Foxp2 gene, which has been linked with human language development.
Furthermore, MSCs can provide tumor cells with CSCs properties by suppressing FOXP2 expression [70].
Neanderthals have the gene FOXP2, associated with the language capacity, but there are very critical differences concerning brain development between our species and Neanderthals.
Michael Lees-Rolfe, Creative Director, FoxP2, South Africa
That said, while most aspects of the presentation are straightforward, at various points a willingness to delve into some of the more technical language of genetics (such as FOXP2, SOX9, BRCA1, SINE, LINE1, Alus, MIR) is required.
It is interesting to note that a speech-language disorder caused by mutations of FOXP2 is associated with impairment of PC dendritic development.